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Does A Single Low Dose of Ionizing Radiation Induce Alzheimer's Disease-Like Alterations in Mice?
https://repo.qst.go.jp/records/70837
https://repo.qst.go.jp/records/708379de3c345-b228-4bdc-bd38-12b3ab60bb4d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-07-25 | |||||
| タイトル | ||||||
| タイトル | Does A Single Low Dose of Ionizing Radiation Induce Alzheimer's Disease-Like Alterations in Mice? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Tanaka, Kaoru× Ki, Hin× Ono, Maiko× Ninomiya, Yasuharu× Maruyama, Kouichi× Nakajima, Nakako× Begum, Nasrin× Higuchi, Makoto× Fujimori, Akira× Uehara, Yoshihiko× Nakajima, Tetsuo× Suhara, Tetsuya× Ono, Tetsuya× Nenoi, Mitsuru× et.al× 王 冰× 田中 薫× 季 斌× 小野 麻衣子× 二宮 康晴× 丸山 耕一× 中島 菜花子× ＢＥＧＵＭ ＮＡＳＲＩＮ× 樋口 真人× 藤森 亮× 中島 徹夫× 須原 哲也× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background A recent study in mice reported early transcriptional response in brain to low-dose X-rays (0.1Gy) suggesting alterations of molecular networks and pathways associated with cognitive functions, advanced aging and Alzheimer's disease (AD). As humans are increasingly exposed to ionizing radiation from various sources including medical diagnosis and space, the possible cognitive and behavioral consequences induced by low-dose ionizing radiation are of great concern. The aim of the present study is to investigate the acute transcriptional responses as well as the late cognitive and behavioral consequences induced by ionizing radiation at low doses. Methods C57BL/6J mice were whole-body irradiated with either X-rays (0.1Gy) or accelerated carbon ions (0.05 Gy or 0.1 Gy). The expression of AD-related genes in the hippocampus was analyzed by RT-PCR-array. The learning ability and memory were measured by Morris Water Maze test. Accumulation of fibrillary amyloid beta peptide (Abeta) was detected by amyloid imaging with positron emission tomography (PET). Characteristic AD pathologies including expression of amyloid precursor protein (APP), Abeta, tau and phosphorylated tau were examined with immunohistochemical staining. Results At 4 hours after radiation significant transcriptional alterations in several AD-related genes were observed but no marked changes were found 1 year later. No significant difference on learning ability and memory was observed 1 and 2 years after irradiation. No detectable accumulation of fibrillar amyloid and the expression of APP, Abeta, tau, phosphorylated tau in the brains of the animals 4 months and 2 years after radiation. Conclusions In mice, a single low dose of ionizing radiation induced significantly acute transcriptional alterations in several AD-related genes while no marked late consequences on behavior al and AD-related pathological changes in brains were observed. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | AAIC>12:Alzheimer's Association International Conference | |||||
| 発表年月日 | ||||||
| 日付 | 2012-07-19 | |||||
| 日付タイプ | Issued | |||||
