@misc{oai:repo.qst.go.jp:00070837,
 author = {Bing, Wang and Tanaka, Kaoru and Ki, Hin and Ono, Maiko and Ninomiya, Yasuharu and Maruyama, Kouichi and Nakajima, Nakako and Begum, Nasrin and Higuchi, Makoto and Fujimori, Akira and Uehara, Yoshihiko and Nakajima, Tetsuo and Suhara, Tetsuya and Ono, Tetsuya and Nenoi, Mitsuru and et.al and 王 冰 and 田中 薫 and 季 斌 and 小野 麻衣子 and 二宮 康晴 and 丸山 耕一 and 中島 菜花子 and ＢＥＧＵＭ ＮＡＳＲＩＮ and 樋口 真人 and 藤森 亮 and 中島 徹夫 and 須原 哲也 and 根井 充},
 month = {Jul},
 note = {Background
A recent study in mice reported early transcriptional response in brain to low-dose X-rays (0.1Gy) suggesting alterations of molecular networks and pathways associated with cognitive functions, advanced aging and Alzheimer's disease (AD). As humans are increasingly exposed to ionizing radiation from various sources including medical diagnosis and space, the possible cognitive and behavioral consequences induced by low-dose ionizing radiation are of great concern. The aim of the present study is to investigate the acute transcriptional responses as well as the late cognitive and behavioral consequences induced by ionizing radiation at low doses.
Methods
C57BL/6J mice were whole-body irradiated with either X-rays (0.1Gy) or accelerated carbon ions (0.05 Gy or 0.1 Gy). The expression of AD-related genes in the hippocampus was analyzed by RT-PCR-array. The learning ability and memory were measured by Morris Water Maze test. Accumulation of fibrillary amyloid beta peptide (Abeta) was detected by amyloid imaging with positron emission tomography (PET). Characteristic AD pathologies including expression of amyloid precursor protein (APP), Abeta, tau and phosphorylated tau were examined with immunohistochemical staining.
Results
At 4 hours after radiation significant transcriptional alterations in several AD-related genes were observed but no marked changes were found 1 year later. No significant difference on learning ability and memory was observed 1 and 2 years after irradiation. No detectable accumulation of fibrillar amyloid and the expression of APP, Abeta, tau, phosphorylated tau in the brains of the animals 4 months and 2 years after radiation.
Conclusions
In mice, a single low dose of ionizing radiation induced significantly acute transcriptional alterations in several AD-related genes while no marked late consequences on behavior al and AD-related pathological changes in brains were observed., AAIC>12:Alzheimer's Association International Conference},
 title = {Does A Single Low Dose of Ionizing Radiation Induce Alzheimer's Disease-Like Alterations in Mice?},
 year = {2012}
}