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Carbon Ion Radiotherapy For Gynecological Melanoma
https://repo.qst.go.jp/records/70748
https://repo.qst.go.jp/records/70748742c1aaa-48fa-47c2-814a-13a9c6c77991
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-05-21 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Radiotherapy For Gynecological Melanoma | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Karasawa, Kumiko
× Karasawa, Kumiko× Wakatuki, Masaru× Ando, Ken× Kato, Shingo× Kiyohara, Hiroki× Kamada, Tadashi× 唐澤 久美子× 若月 優× 安藤 謙× 加藤 眞吾× 清原 浩樹× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective : A clinical trial of carbon ion radiotherapy for gynecological melanoma was conducted under the Phase I/II clinical trial to assess the toxicity and efficacy. \nMethods : The eligibility criteria for enrollment in this study were (1) histologically proven malignant melanoma, (2) a localized measurable tumor in gynecological region, (3) at least a 5mm gap between the tumor and radiosensitive organs, including bowel and bladder, and (4) a expected prognosis of more than 6 months. In principle, tumors and surrounding areas were irradiated 3.6 GyE per fraction up to the total dose of 57.6 GyE in 16 fractions, 4 times a week. Toxicities were assessed weekly and graded according to NCI-CTCAE ver.4.0. Treatment response was assessed at 3 month after treatment completion. Statistical analysis of survival was calculated using the Kaplan-Meier method. \nResults : A series of 21 gynecological melanoma patients were treated with carbon ion radiotherapy between November 2004 and October 2011. The age ranged from 51 to 80 with a median of 71. The tumor sites were vagina in 13, vulva in 3, uterine cervix in 3 and vagina and vulva in 2. The clinical stage was stage I in 3, stage II in 9, stage III in 5, stage IVB in 1 and 3 patients had local recurrent tumor. The irradiated dose was 57.6 GyE in 20 and 64 GyE in 1. Twelve patients were treated with DAV-Feron regime (DTIC, ACNU, VCR, IFN-) and 4 patients treated with IFN- only for induction and /or adjuvant therapy. One patient had used IFN- during radiotherapy. Greater than 2 acute toxicities were observed with regard to grade 3 skin reaction in 2, grade 2 skin reaction in 4 and grade 2 urinary tract reaction in 1. The median follow-up times were 15 months (range 3-53 months) in all patients, 15 months (range 3-43 months) in the living and 16 months (range 11-53 months) in the dead. One patient who had been treated concurrent IFN- developed sepsis induced by urinary tract infection after 3 months from the completion of radiotherapy. Thirteen patients have recurred, in-field in 3, marginal field in 3, regional lymph node in 6 and distant in 6. All T1 tumors and all vulval tumors were locally controlled. Ten of 21 patients were dead, one was intercurrent disease and other 9 were of melanoma. The 2-year local control rate, disease free rate and overall survival rate were 71%, 38% and 53% respectively. \nConclusions : Carbon ion radiotherapy is as effective as surgery for gynecological melanoma. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 51st Annual Meeting of Particle Therapy Co-Operative Group | |||||
| 発表年月日 | ||||||
| 日付 | 2012-05-19 | |||||
| 日付タイプ | Issued | |||||
