{"created":"2023-05-15T14:51:45.272416+00:00","id":70748,"links":{},"metadata":{"_buckets":{"deposit":"af2665b9-5952-4551-a887-0640799831a0"},"_deposit":{"created_by":1,"id":"70748","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70748"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070748","sets":["10:28"]},"author_link":["694994","694993","694992","694996","694997","695003","695000","694995","695002","694999","694998","695001"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-19","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective : A clinical trial of carbon ion radiotherapy for gynecological melanoma was conducted under the Phase I/II clinical trial to assess the toxicity and efficacy.\n\\nMethods : The eligibility criteria for enrollment in this study were (1) histologically proven malignant melanoma, (2) a localized measurable tumor in gynecological region, (3) at least a 5mm gap between the tumor and radiosensitive organs, including bowel and bladder, and (4) a expected prognosis of more than 6 months. In principle, tumors and surrounding areas were irradiated 3.6 GyE per fraction up to the total dose of 57.6 GyE in 16 fractions, 4 times a week. Toxicities were assessed weekly and graded according to NCI-CTCAE ver.4.0. Treatment response was assessed at 3 month after treatment completion. Statistical analysis of survival was calculated using the Kaplan-Meier method.\n\\nResults : A series of 21 gynecological melanoma patients were treated with carbon ion radiotherapy between November 2004 and October 2011. The age ranged from 51 to 80 with a median of 71. The tumor sites were vagina in 13, vulva in 3, uterine cervix in 3 and vagina and vulva in 2. The clinical stage was stage I in 3, stage II in 9, stage III in 5, stage IVB in 1 and 3 patients had local recurrent tumor. The irradiated dose was 57.6 GyE in 20 and 64 GyE in 1. Twelve patients were treated with DAV-Feron regime (DTIC, ACNU, VCR, IFN-) and 4 patients treated with IFN- only for induction and /or adjuvant therapy. One patient had used IFN- during radiotherapy. Greater than 2 acute toxicities were observed with regard to grade 3 skin reaction in 2, grade 2 skin reaction in 4 and grade 2 urinary tract reaction in 1. The median follow-up times were 15 months (range 3-53 months) in all patients, 15 months (range 3-43 months) in the living and 16 months (range 11-53 months) in the dead. One patient who had been treated concurrent IFN- developed sepsis induced by urinary tract infection after 3 months from the completion of radiotherapy. Thirteen patients have recurred, in-field in 3, marginal field in 3, regional lymph node in 6 and distant in 6. All T1 tumors and all vulval tumors were locally controlled. Ten of 21 patients were dead, one was intercurrent disease and other 9 were of melanoma. The 2-year local control rate, disease free rate and overall survival rate were 71%, 38% and 53% respectively.\n\\nConclusions : Carbon ion radiotherapy is as effective as surgery for gynecological melanoma.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"51st Annual Meeting of Particle Therapy Co-Operative Group","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Karasawa, Kumiko"}],"nameIdentifiers":[{"nameIdentifier":"694992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakatuki, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"694993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Ken"}],"nameIdentifiers":[{"nameIdentifier":"694994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Shingo"}],"nameIdentifiers":[{"nameIdentifier":"694995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiyohara, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"694996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"694997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"唐澤 久美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"若月 優","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 謙","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 眞吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清原 浩樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695003","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Carbon Ion Radiotherapy For Gynecological Melanoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon Ion Radiotherapy For Gynecological Melanoma"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-21"},"publish_date":"2012-05-21","publish_status":"0","recid":"70748","relation_version_is_last":true,"title":["Carbon Ion Radiotherapy For Gynecological Melanoma"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:59:17.333172+00:00"}