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Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterine cervix
https://repo.qst.go.jp/records/70743
https://repo.qst.go.jp/records/70743cbd8e7a6-4a9d-47b7-8527-760859f9c154
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-05-16 | |||||
| タイトル | ||||||
| タイトル | Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterine cervix | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wakatuki, Masaru
× Wakatuki, Masaru× Kato, Shingo× Ohno, Tatsuya× Karasawa, Kumiko× Ando, Ken× Kiyohara, Hiroki× Nakano, Takashi× Kamada, Tadashi× Syozu, Makio× 若月 優× 加藤 眞吾× 唐澤 久美子× 安藤 謙× 鎌田 正× 生水 真紀夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose/Objective; To evaluate the toxicity and efficacy of carbon ion radiotherapy (C-ion RT) forlocally advanced adenocarcinoma and adenosquamous carcinoma of the uterine cervix by phase I/II clinical trials. Material/Methods; The treatment consisted of 12 fractions of whole pelvic irradiation, 8 fractions of extended local boost. The whole pelvic dose was fixed at 36.0 gray equivalents (GyE). With regard to local boost, a dose-escalation study was planned with an initial dose of 26.4 GyE for 8 fractions and then gradually increased up to 38.4 GyE for 8 fractions by 2.4 or 3.6 GyE increments. At least 5 patients were treated at the same dose level, and dose escalation was performed after careful observation of acute normal tissue responses. Total dose to the cervical tumor was 62.4-74.4 GyE for 20 fractions. Results; Between April 1998 and February 2010, 58 patients of locally advanced adenocarcinoma were treated with C-ion RT in this clinical trial. Median age was 59 years (range, 28-85 years). Twenty patients had stage IIB disease, 35 patients had stage IIIB disease, and 3 patients had stage IVA disease. Median tumor size was 5.5 cm (range, 3.0-11.8 cm). Histologically, 48 patients had adenocarcinoma and 10 patients had adenosquamous cell carcinoma. Twenty-seven patients had lymph node metastases in the pelvis. The median follow-up period for surviving and all patients were 44 and 31 months, respectively. Although 23 patients developed acute toxicity (G1-G3), all patients completed the scheduled therapy. Late toxicity was found in as many as 19 patients but toxicity observed was G1 or G2 except one: G1 toxicity was found 15 patients (24%): 12 patients for rectum/sigmoid, 4 for small intestine and 6 for bladder. G2 toxicity was detected 7 patients (12 %): 5 patients for bladder and 2 patients for small intestine. Only exception was G4 for rectal complication, which was surgically salvaged. Complete response rate and partial response rate for C-ion RT were 60.3% and 34.5%, respectively. Twenty-seven patients (46.6%) had local recurrence, and ten of which received salvage surgery. The 3-year local control rate and overall survival rate were 53.4% and 53.4% respectively. Thirty-six patients (62.1%) had distant metastases. The overall 3-year local control rate including salvage surgery was 62.9%. Conclusions; Carbone ion radiotherapy is a safe and effective treatment for locally advanced adenocarcinoma of the uterine cervix. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | European Society for Therapeutic Radiology and Oncology 31（ESTRO31） | |||||
| 発表年月日 | ||||||
| 日付 | 2012-05-13 | |||||
| 日付タイプ | Issued | |||||
