{"created":"2023-05-15T14:51:45.057744+00:00","id":70743,"links":{},"metadata":{"_buckets":{"deposit":"47d34ee8-cec1-4505-9fd3-aaf54a54123e"},"_deposit":{"created_by":1,"id":"70743","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70743"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070743","sets":["10:28"]},"author_link":["694933","694938","694936","694935","694934","694940","694942","694930","694941","694943","694937","694939","694932","694931","694929"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose/Objective;\nTo evaluate the toxicity and efficacy of carbon ion radiotherapy (C-ion RT) forlocally advanced adenocarcinoma and adenosquamous carcinoma of the uterine cervix by phase I/II clinical trials.\nMaterial/Methods;\nThe treatment consisted of 12 fractions of whole pelvic irradiation, 8 fractions of extended local boost. The whole pelvic dose was fixed at 36.0 gray equivalents (GyE). With regard to local boost, a dose-escalation study was planned with an initial dose of 26.4 GyE for 8 fractions and then gradually increased up to 38.4 GyE for 8 fractions by 2.4 or 3.6 GyE increments. At least 5 patients were treated at the same dose level, and dose escalation was performed after careful observation of acute normal tissue responses. Total dose to the cervical tumor was 62.4-74.4 GyE for 20 fractions. \nResults;\nBetween April 1998 and February 2010, 58 patients of locally advanced adenocarcinoma were treated with C-ion RT in this clinical trial. Median age was 59 years (range, 28-85 years). Twenty patients had stage IIB disease, 35 patients had stage IIIB disease, and 3 patients had stage IVA disease. Median tumor size was 5.5 cm (range, 3.0-11.8 cm). Histologically, 48 patients had adenocarcinoma and 10 patients had adenosquamous cell carcinoma. Twenty-seven patients had lymph node metastases in the pelvis. The median follow-up period for surviving and all patients were 44 and 31 months, respectively. Although 23 patients developed acute toxicity (G1-G3), all patients completed the scheduled therapy. Late toxicity was found in as many as 19 patients but toxicity observed was G1 or G2 except one: G1 toxicity was found 15 patients (24%): 12 patients for rectum/sigmoid, 4 for small intestine and 6 for bladder. G2 toxicity was detected 7 patients (12 %): 5 patients for bladder and 2 patients for small intestine.  Only exception was G4 for rectal complication, which was surgically salvaged. Complete response rate and partial response rate for C-ion RT were 60.3% and 34.5%, respectively. Twenty-seven patients (46.6%) had local recurrence, and ten of which received salvage surgery. The 3-year local control rate and overall survival rate were 53.4% and 53.4% respectively. Thirty-six patients (62.1%) had distant metastases. The overall 3-year local control rate including salvage surgery was 62.9%.\nConclusions;\nCarbone ion radiotherapy is a safe and effective treatment for locally advanced adenocarcinoma of the uterine cervix.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"European Society for Therapeutic Radiology and Oncology　31（ESTRO31）","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wakatuki, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"694929","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Shingo"}],"nameIdentifiers":[{"nameIdentifier":"694930","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohno, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"694931","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Karasawa, Kumiko"}],"nameIdentifiers":[{"nameIdentifier":"694932","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Ken"}],"nameIdentifiers":[{"nameIdentifier":"694933","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiyohara, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"694934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"694935","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"694936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Syozu, Makio"}],"nameIdentifiers":[{"nameIdentifier":"694937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"若月 優","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 眞吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"唐澤 久美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 謙","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生水 真紀夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694943","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterine cervix","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterine cervix"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-16"},"publish_date":"2012-05-16","publish_status":"0","recid":"70743","relation_version_is_last":true,"title":["Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterine cervix"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:59:21.343480+00:00"}