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Mitochondrial dysfunction induced by heavy-ion radiation in mouse brain: Does hypoxia play a role?
https://repo.qst.go.jp/records/70730
https://repo.qst.go.jp/records/707302478c227-7835-4c2d-89f4-1c8d3bf151ee
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-04-25 | |||||
| タイトル | ||||||
| タイトル | Mitochondrial dysfunction induced by heavy-ion radiation in mouse brain: Does hypoxia play a role? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wang, Zhenhua
× Wang, Zhenhua× Hong, Zhang× Bing, Wang× Tanaka, Kaoru× Zhou, Xin× Liu, Yang× Gan, Lu× Sun, Chao× Ｗａｎｇ Ｚｈｅｎｈｕａ× Ｈｏｎｇ Ｚｈａｎｇ× 王 冰× 田中 薫× Ｚｈｏｕ Ｘｉｎ× Ｌｉｕ Ｙａｎｇ× Ｇａｎ Ｌｕ× Ｓｕｎ Ｃｈａｏ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation induced brain injury (RBI) is the most serious adverse reaction in cranial radiotherapy, which will cause the loss of neurons and cerebral capillary and finally result in the cognitive impairment. As the power house of cells, mitochondria play the essential role in keeping the stabilization of brain energy metabolism. However, the mitochondrial DNA (mtDNA) is a vulnerable target of irradiation, the injury of mtDNA might be the root of RBI. Here we investigted the mtDNA injury and the cerebral ischemia induced by carbon ions or X-rays. The long PCR results indicated that both carbon ions and X-rays caused the mtDNA injury and upregulated the expression of HIF-1arufa. The mtDNA injury and expression of HIF-1arufa maintained in high level in carbon ions irradiated group, whereas they recovered to the control level in X-rays irradiated group which indicated that the injury induced by carbon ions is more difficult to repair in brain tissue. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成23年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2012-04-24 | |||||
| 日付タイプ | Issued | |||||
