@misc{oai:repo.qst.go.jp:00070730,
 author = {Wang, Zhenhua and Hong, Zhang and Bing, Wang and Tanaka, Kaoru and Zhou, Xin and Liu, Yang and Gan, Lu and Sun, Chao and Ｗａｎｇ Ｚｈｅｎｈｕａ and Ｈｏｎｇ Ｚｈａｎｇ and 王 冰 and 田中 薫 and Ｚｈｏｕ Ｘｉｎ and Ｌｉｕ Ｙａｎｇ and Ｇａｎ Ｌｕ and Ｓｕｎ Ｃｈａｏ},
 month = {Apr},
 note = {Radiation induced brain injury (RBI) is the most serious adverse reaction in cranial radiotherapy, which will cause the loss of neurons and cerebral capillary and finally result in the cognitive impairment. As the  power house  of cells, mitochondria play the essential role in keeping the stabilization of brain energy metabolism. However, the mitochondrial DNA (mtDNA) is a vulnerable target of irradiation, the injury of mtDNA might be the root of RBI. Here we investigted the mtDNA injury and the cerebral ischemia induced by carbon ions or X-rays. The long PCR results indicated that both carbon ions and X-rays caused the mtDNA injury and upregulated the expression of HIF-1arufa. The mtDNA injury and expression of HIF-1arufa maintained in high level in carbon ions irradiated group, whereas they recovered to the control level in X-rays irradiated group which indicated that the injury induced by carbon ions is more difficult to repair in brain tissue., 平成23年度HIMAC共同利用研究成果発表会},
 title = {Mitochondrial dysfunction induced by heavy-ion radiation in mouse brain: Does hypoxia play a role?},
 year = {2012}
}