WEKO3
アイテム
デキストラン硫酸誘発マウス潰瘍性大腸炎の再生過程における組織病理及び分子病理学的解析
https://repo.qst.go.jp/records/70571
https://repo.qst.go.jp/records/705713590a45e-4f99-43af-9bd4-ac0b6b2fa523
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-13 | |||||
| タイトル | ||||||
| タイトル | デキストラン硫酸誘発マウス潰瘍性大腸炎の再生過程における組織病理及び分子病理学的解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
森岡, 孝満
× 森岡, 孝満× 柿沼, 志津子× 臺野, 和広× 西村, まゆみ× 今岡, 達彦× 吉見, 直己× 島田, 義也× 森岡 孝満× 柿沼 志津子× 臺野 和広× 西村 まゆみ× 今岡 達彦× 島田 義也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ulcerative colitis is a chronic inflammatory disease, which is characterized by cycles of mucosal ulceration accompanied by necrosis and regeneration of colonic mucosa. This necrosis-regeneration cycle would in theory be linked to neoplastic transformation of normal mucosal epithelia. In this study, six-week-old C57BL/6J male mice were induced ulcerative colitis by administering 1 or 2% dextran sodium sulfate (DSS) for 7 days. Up until 3 weeks after DSS treatment, we examined sequentially the mucosal regeneration process histopathologically. Mucin-depleted foci (MDF), which are considered as precancerous lesions of colon carcinoma, were recognized just after completion (day 0) of DSS administration in the adjacent ulcerated lesions. Aberrant crypt foci-like lesions (ACF-L) were observed at day 2 after DSS administration in the same area (as MDF). The lesions having characteristics of both MDF and ACF-L showed the atypical changes with nuclear stratification, loss of nuclear polarity and structural abnormality of the crypts. Analysis in the global gene expression during the regeneration process is now undertaken. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第70回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2011-10-05 | |||||
| 日付タイプ | Issued | |||||
