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放射線誘発マウス胸腺リンパ腫のポジトロン断層撮像法と磁気共鳴イメージング
https://repo.qst.go.jp/records/70562
https://repo.qst.go.jp/records/70562274de6de-f481-4a84-8886-d83d60d4063f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-06 | |||||
| タイトル | ||||||
| タイトル | 放射線誘発マウス胸腺リンパ腫のポジトロン断層撮像法と磁気共鳴イメージング | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
長谷川, 純崇
× 長谷川, 純崇× 古川, 高子× 佐賀, 恒夫× 長谷川 純崇× 古川 高子× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Molecular imaging using positron emission tomography (PET) and magnetic resonance imaging (MRI) are widely used not only for clinical cancer diagnostics but also for animal models of cancer. Here we show in vivo imaging of radiation-induced mouse thymic lymphoma (TL) by PET and MRI. We used fractionated whole body X-ray irradiation to induce TL in mice. Four weeks-old C57BL/6 mice were X-ray irradiated at 1.2 Gy/week for 4 consecutive weeks. Three to six months after irradiation, affected mice showed weight loss and difficulty in breathing. T1-weighted images using 7T-MRI scanner were acquired to evaluate the size of thymus of these affected mice. PET with [18F]fluorodeoxyglucose (FDG) was also applied to mice with an enlarged thymus. FDG was highly accumulated in the affected thymus, suggesting that the lesions were metabolically active and malignant. Histopathology revealed that they were T-cell lymphomas. Molecular imaging using PET and MRI allows us to trace the process of mouse TL development in living animals. Therefore, we propose that these techniques would offer a new opportunity to understand the molecular and cellular mechanism(s) of radiation-induced lymphomagenesis. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第70回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2011-10-05 | |||||
| 日付タイプ | Issued | |||||
