@misc{oai:repo.qst.go.jp:00070562,
 author = {長谷川, 純崇 and 古川, 高子 and 佐賀, 恒夫 and 長谷川 純崇 and 古川 高子 and 佐賀 恒夫},
 month = {Oct},
 note = {Molecular imaging using positron emission tomography (PET) and magnetic resonance imaging (MRI) are widely used not only for clinical cancer diagnostics but also for animal models of cancer. Here we show in vivo imaging of radiation-induced mouse thymic lymphoma (TL) by PET and MRI. We used fractionated whole body X-ray irradiation to induce TL in mice. Four weeks-old C57BL/6 mice were X-ray irradiated at 1.2 Gy/week for 4 consecutive weeks. Three to six months after irradiation, affected mice showed weight loss and difficulty in breathing. T1-weighted images using 7T-MRI scanner were acquired to evaluate the size of thymus of these affected mice. PET with [18F]fluorodeoxyglucose (FDG) was also applied to mice with an enlarged thymus. FDG was highly accumulated in the affected thymus, suggesting that the lesions were metabolically active and malignant. Histopathology revealed that they were T-cell lymphomas. Molecular imaging using PET and MRI allows us to trace the process of mouse TL development in living animals. Therefore, we propose that these techniques would offer a new opportunity to understand the molecular and cellular mechanism(s) of radiation-induced lymphomagenesis., 第70回日本癌学会学術総会},
 title = {放射線誘発マウス胸腺リンパ腫のポジトロン断層撮像法と磁気共鳴イメージング},
 year = {2011}
}