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NRARPは細胞周期を制御して乳がん細胞の増殖に寄与する
https://repo.qst.go.jp/records/70560
https://repo.qst.go.jp/records/7056042c33058-e203-4177-94eb-7be76f3d6c57
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-06 | |||||
| タイトル | ||||||
| タイトル | NRARPは細胞周期を制御して乳がん細胞の増殖に寄与する | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
奥谷, 倫未
× 奥谷, 倫未× 今岡, 達彦× 臺野, 和広× 西村, まゆみ× 島田, 義也× 奥谷 倫未× 今岡 達彦× 臺野 和広× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Gene expression profiles are frequently altered in various types of cancers. We previously identified that the expression of NRARP was increased in rat mammary cancers. In the present study, we investigated its functions in a human breast cancer cell line MCF7. NRARP was knocked down by RNA interference in MCF7 cells. Cell proliferation was determined by cell counting with hemocytometers. Gene expressions were quantified with real-time PCR. As a result, NRARP was overexpressed in MCF7 cells compared to a non-transformed human breast epithelial MCF10A cells. Knockdown of NRARP inhibited the proliferation of MCF7 cells. Expression of CCND1 was significantly down regulated. Other G1 phase related genes,CCNE1, TFDP1 and TFDP2 were also down regulated by NRARP knockdown. These results suggested that cell growth inhibition by NRARP knockdown is caused by cell cycle arrest at G1 phase, and that NRARP is a novel protooncogene involved in proliferation of breast cancer cells through the cell cycle. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第70回 日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2011-10-05 | |||||
| 日付タイプ | Issued | |||||
