@misc{oai:repo.qst.go.jp:00070560,
 author = {奥谷, 倫未 and 今岡, 達彦 and 臺野, 和広 and 西村, まゆみ and 島田, 義也 and 奥谷 倫未 and 今岡 達彦 and 臺野 和広 and 西村 まゆみ and 島田 義也},
 month = {Oct},
 note = {Gene expression profiles are frequently altered in various types of cancers. We previously identified that the expression of NRARP was increased in rat mammary cancers. In the present study, we investigated its functions in a human breast cancer cell line MCF7. NRARP was knocked down by RNA interference in MCF7 cells. Cell proliferation was determined by cell counting with hemocytometers. Gene expressions were quantified with real-time PCR. As a result, NRARP was overexpressed in MCF7 cells compared to a non-transformed human breast epithelial MCF10A cells. Knockdown of NRARP inhibited the proliferation of MCF7 cells. Expression of CCND1 was significantly down regulated. Other G1 phase related genes,CCNE1, TFDP1 and TFDP2 were also down regulated by NRARP knockdown. These results suggested that cell growth inhibition by NRARP knockdown is caused by cell cycle arrest at G1 phase, and that NRARP is a novel protooncogene involved in proliferation of breast cancer cells through the cell cycle., 第70回　日本癌学会学術総会},
 title = {NRARPは細胞周期を制御して乳がん細胞の増殖に寄与する},
 year = {2011}
}