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Assessment of 11C-2-Aminoisobutyric Acid in Nude Mice with Tumor and Inflammation
https://repo.qst.go.jp/records/70519
https://repo.qst.go.jp/records/705195ba37295-69c6-4c8a-a8e9-501deb7ecdf9
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-09-07 | |||||
| タイトル | ||||||
| タイトル | Assessment of 11C-2-Aminoisobutyric Acid in Nude Mice with Tumor and Inflammation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tsuji, Atsushi
× Tsuji, Atsushi× Kato, Koichi× Sugyou, Aya× Sudou, Hitomi× Yoshida, Chisato× Zhang, Ming-Rong× Saga, Tsuneo× 辻 厚至× 加藤 孝一× 須尭 綾× 須藤 仁美× 吉田 千里× 張 明栄× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: 18F-fluoro-deoxy-D-glucose (FDG) highly accumulates in tumors and is widely used for cancer diagnosis. However, 18F-FDG also accumulates in therapy-induced inflammatory changes within tumors. We, therefore, need a new PET tracer that selectively accumulates in viable tumor cells but not in inflammatory cells for more precise diagnosis of therapy response. 2-Aminoisobutyric Acid (AIB) is a non-metabolized analog of alanine and a substrate of system A. Since system A is an unidirectional amino acid transporter, AIB is directly concentrated in cells. Although several studies showed that 11C-AIB highly accumulated in tumors in animal models and in patients, the synthesis methods used in those studies are not suitable to use for a routine production. Recently, we developed a simple and efficient synthesis method [1] applicable for a routine use. To assess whether 11C-AIB is useful for therapy response diagnosis or not, we evaluated tumor and inflammation uptake of 11C-AIB compared with that of 18F-FDG using biodistribution and small animal PET experiments in a animal model having both tumor and inflammation. Methods: BALB/c-nu/nu male mice were subcutaneously inoculated with small cell lung cancer SY cells in right lower flank region. At 24 to 30 h before experiments, turpentine was intramuscularly injected into left hind leg. For biodistribution study, at 15, 30, 60 and 90 min after intravenous (i.v.) injection of 11C-AIB, or 30 and 60 min after i.v. injection of 18F-FDG, blood and major organs were removed and weighted, and the radioactivity was measured. For PET experiment, we first conducted PET imaging with 11C-AIB and, 6 h later, 18F-FDG PET in the same mouse. Serial PET data were acquired for 60 min after i.v. injection of each tracer. Tracer uptake was semi-quantified as standardized uptake value (SUV). Results: Biodistribution and PET experiments showed that tumor uptake of 11C-AIB increased with time and was higher than that of 18F-FDG. SUVmax of tumors of 11C-AIB and 18F-FDG were 3.03+-0.51 and 1.6+-0.24 at 50-60 min, respectively. In contrast, the uptake in inflamed sites of 11C-AIB was lower than that of 18F-FDG. SUVmax of inflamed sites of 11C-AIB and 18F-FDG were 0.7+-0.10 at 3-4 min and 1.14+-0.06 at 50-60 min, respectively. Tumor-to-inflamed site ratio of 11C-AIB was higher than that of 18F-FDG, while inflamed site-to-muscle ratio of 11C-AIB was lower than that of 18F-FDG. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 19th International Symposium on Radiopharmaceutical Sciences, the ISRS 2011. | |||||
| 発表年月日 | ||||||
| 日付 | 2011-09-02 | |||||
| 日付タイプ | Issued | |||||
