{"created":"2023-05-15T14:51:35.266630+00:00","id":70519,"links":{},"metadata":{"_buckets":{"deposit":"924681b3-06c3-4d30-843e-fd250c6ab75e"},"_deposit":{"created_by":1,"id":"70519","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70519"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070519","sets":["10:28"]},"author_link":["692562","692568","692564","692556","692565","692558","692566","692557","692561","692555","692567","692560","692559","692563"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-09-02","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: 18F-fluoro-deoxy-D-glucose (FDG) highly accumulates in tumors and is widely used for cancer diagnosis. However, 18F-FDG also accumulates in therapy-induced inflammatory changes within tumors. We, therefore, need a new PET tracer that selectively accumulates in viable tumor cells but not in inflammatory cells for more precise diagnosis of therapy response. 2-Aminoisobutyric Acid (AIB) is a non-metabolized analog of alanine and a substrate of system A. Since system A is an unidirectional amino acid transporter, AIB is directly concentrated in cells. Although several studies showed that 11C-AIB highly accumulated in tumors in animal models and in patients, the synthesis methods used in those studies are not suitable to use for a routine production. Recently, we developed a simple and efficient synthesis method [1] applicable for a routine use. To assess whether 11C-AIB is useful for therapy response diagnosis or not, we evaluated tumor and inflammation uptake of 11C-AIB compared with that of 18F-FDG using biodistribution and small animal PET experiments in a animal model having both tumor and inflammation.\nMethods: BALB/c-nu/nu male mice were subcutaneously inoculated with small cell lung cancer SY cells in right lower flank region. At 24 to 30 h before experiments, turpentine was intramuscularly injected into left hind leg. For biodistribution study, at 15, 30, 60 and 90 min after intravenous (i.v.) injection of 11C-AIB, or 30 and 60 min after i.v. injection of 18F-FDG, blood and major organs were removed and weighted, and the radioactivity was measured. For PET experiment, we first conducted PET imaging with 11C-AIB and, 6 h later, 18F-FDG PET in the same mouse. Serial PET data were acquired for 60 min after i.v. injection of each tracer. Tracer uptake was semi-quantified as standardized uptake value (SUV).\nResults: Biodistribution and PET experiments showed that tumor uptake of 11C-AIB increased with time and was higher than that of 18F-FDG. SUVmax of tumors of 11C-AIB and 18F-FDG were 3.03+-0.51 and 1.6+-0.24 at 50-60 min, respectively. In contrast, the uptake in inflamed sites of 11C-AIB was lower than that of 18F-FDG. SUVmax of inflamed sites of 11C-AIB and 18F-FDG were 0.7+-0.10 at 3-4 min and 1.14+-0.06 at 50-60 min, respectively. Tumor-to-inflamed site ratio of 11C-AIB was higher than that of 18F-FDG, while inflamed site-to-muscle ratio of 11C-AIB was lower than that of 18F-FDG.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"19th International Symposium on Radiopharmaceutical Sciences, the ISRS 2011.","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsuji, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"692555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"692556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugyou, Aya"}],"nameIdentifiers":[{"nameIdentifier":"692557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sudou, Hitomi"}],"nameIdentifiers":[{"nameIdentifier":"692558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Chisato"}],"nameIdentifiers":[{"nameIdentifier":"692559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"692560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"692561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 孝一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭 綾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤 仁美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 千里","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692568","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Assessment of 11C-2-Aminoisobutyric Acid in Nude Mice with Tumor and Inflammation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Assessment of 11C-2-Aminoisobutyric Acid in Nude Mice with Tumor and Inflammation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-09-07"},"publish_date":"2011-09-07","publish_status":"0","recid":"70519","relation_version_is_last":true,"title":["Assessment of 11C-2-Aminoisobutyric Acid in Nude Mice with Tumor and Inflammation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:01:59.446742+00:00"}