WEKO3
アイテム
Reaction of Melatonin with Free Radicals in a Protic Medium and the Mechanism
https://repo.qst.go.jp/records/70386
https://repo.qst.go.jp/records/70386686a908c-5264-442f-9f90-41f90281eeb7
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-01-24 | |||||
| タイトル | ||||||
| タイトル | Reaction of Melatonin with Free Radicals in a Protic Medium and the Mechanism | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakanishi, Ikuo
× Nakanishi, Ikuo× Kabir, ZOARDAR× Kamibayashi, Masato× Ohkubo, Kei× Kawashima, Tomonori× Matsumoto, Kenichiro× Fukuzumi, Shunichi× Ozawa, Toshihiko× Anzai, Kazunori× 中西 郁夫× カビル ゾーダー× 上林 將人× 川島 知憲× 松本 謙一郎 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Melatonin (N-acetyl-5-methoxytryptamine), a pineal hormone, is known to show efficient antioxidative activities. It is also known that melatonin significantly protects mice against whole-body X-ray irradiation. However, very little is known about the detailed mechanisms of such activities of melatonin. In this study, we demonstrate that melatonin scavenges galvinoxyl and 2,2-diphenyl-1-picrylhydrazyl radicals via an electron transfer from melatonin to the radicals rather than via a one-step hydrogen atom transfer in methanol. The kinetic data together with the calculated thermodynamic parameters obtained in this study provide a detailed mechanistic insight into the antioxidative activities of melatonin. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | International Symposium on Free Radical Research: Contribution to Medicine | |||||
| 発表年月日 | ||||||
| 日付 | 2011-01-22 | |||||
| 日付タイプ | Issued | |||||
