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Long-term risk of second cancers after cervical cancer treated with radiotherapy
https://repo.qst.go.jp/records/70369
https://repo.qst.go.jp/records/70369cdc023a6-e4b4-417f-9f0f-b2a2639944d2
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-12-21 | |||||
| タイトル | ||||||
| タイトル | Long-term risk of second cancers after cervical cancer treated with radiotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ohno, Tatsuya
× Ohno, Tatsuya× 大野 達也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract Purpose: Occurrence of a second cancer is the most serious event among long-term survivors after radiotherapy (RT). The purpose of this study was to evaluate the risk of second cancers after cervical cancer treated with RT. Methods and Materials: We reviewed 2,167 patients with uterine cervical cacer undergoing RT between 1961 and 1986 at the National Institute of Radiological Sciences. Among them, 1,702 (79%) patients were treated with RT-alone group and 465 (21%) received postoperative RT. Their mean age was 60 years in the RT alone and 49 years in the postoperative RT group. Intracavitary brachytherapy was performed with high-dose rate source (82%) or low-dose rate source (18%) for RT alone. Relative risk (RR) of second cancer was calculated using the Japanese disease expectancy table. RR of second cancer was calculated by age at RT and the post-RT duration of follow-up. Results: The total number of person-years of follow-up was 25,771, with 60 patients being lost to follow-up. Among 2,167 patients, 1,063 patients (49%) survived more than 10 years. Second cancers developed in 210 patients, which represented a significant increase in risk compared with a comparable normal population (RR = 1.24, 95%CI = 1.08-1.42). RR of developing a second cancer was significantly elevated for patients younger than 60 years at RT (RR = 1.33, 95%CI = 1.10-1.61) and for patients with post-RT follow-up between 5 and 15 years (RR = 1.31, 95%CI = 1.06-1.62). The estimated cumulative probability for development of a second cancer was 6.7% at 10 years, 15.6% at 20 years, and 23.8% at 30 years. Conclusions: Significant increased risk of second cancers was observed among long-term survivors after RT for cervical cancer. RR differed by age at RT and interval of follow-up after RT, helping us to identify a high-risk population for the development of second cancers. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ASTRO 48ｔｈ Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2006-11-09 | |||||
| 日付タイプ | Issued | |||||
