{"created":"2023-05-15T14:51:28.703444+00:00","id":70369,"links":{},"metadata":{"_buckets":{"deposit":"61d05d80-f8d6-4f2a-a0ca-6c30631b35a4"},"_deposit":{"created_by":1,"id":"70369","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70369"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070369","sets":["10:28"]},"author_link":["690994","690993"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2006-11-09","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract\nPurpose: Occurrence of a second cancer is the most serious event among long-term survivors after radiotherapy (RT). The purpose of this study was to evaluate the risk of second cancers after cervical cancer treated with RT.\nMethods and Materials: We reviewed 2,167 patients with uterine cervical cacer undergoing RT between 1961 and 1986 at the National Institute of Radiological Sciences. Among them, 1,702 (79%) patients were treated with RT-alone group and 465 (21%) received postoperative RT. Their mean age was 60 years in the RT alone and 49 years in the postoperative RT group. Intracavitary brachytherapy was performed with high-dose rate source (82%) or low-dose rate source (18%) for RT alone. Relative risk (RR) of second cancer was calculated using the Japanese disease expectancy table. RR of second cancer was calculated by age at RT and the post-RT duration of follow-up.\n Results: The total number of person-years of follow-up was 25,771, with 60 patients being lost to follow-up. Among 2,167 patients, 1,063 patients (49%) survived more than 10 years. Second cancers developed in 210 patients, which represented a significant increase in risk compared with a comparable normal population (RR = 1.24, 95%CI = 1.08-1.42). RR of developing a second cancer was significantly elevated for patients younger than 60 years at RT (RR = 1.33, 95%CI = 1.10-1.61) and for patients with post-RT follow-up between 5 and 15 years (RR = 1.31, 95%CI = 1.06-1.62). The estimated cumulative probability for development of a second cancer was 6.7% at 10 years, 15.6% at 20 years, and 23.8% at 30 years.  \nConclusions: Significant increased risk of second cancers was observed among long-term survivors after RT for cervical cancer. RR differed by age at RT and interval of follow-up after RT, helping us to identify a high-risk population for the development of second cancers.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"ASTRO 48ｔｈ Annual Meeting","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohno, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"690993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"690994","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Long-term risk of second cancers after cervical cancer treated with radiotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Long-term risk of second cancers after cervical cancer treated with radiotherapy"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-12-21"},"publish_date":"2010-12-21","publish_status":"0","recid":"70369","relation_version_is_last":true,"title":["Long-term risk of second cancers after cervical cancer treated with radiotherapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:03:43.994801+00:00"}