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Expression profiles of miRNA in A549 cell line exposed to carbon ion irradiation
https://repo.qst.go.jp/records/70362
https://repo.qst.go.jp/records/70362e386f9af-860f-473c-86e4-4c1da8eea115
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-12-13 | |||||
| タイトル | ||||||
| タイトル | Expression profiles of miRNA in A549 cell line exposed to carbon ion irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference output | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishikawa, Kenichi
× Ishikawa, Kenichi× Ishikawa, Atsuko× Shoji, Yoshimi× Imai, Takashi× 石川 顕一× 石川 敦子× 荘司 好美× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Changes in microRNA (miRNA) expression in response to photon irradiation have been analyzed in a variety of cell lines including cells derived from breast, lung, prostate, and oral cancers. Several different miRNAs were responsive to the irradiation. Interestingly, individual miRNA species showing a response in specific cell types were not identified in other cells. These previous studies therefore suggested that selected miRNAs are regulated in a cell- or tumor-specific manner.<BR>C-ions with high energy transfer (LET) have a major big advantage over X-rays in treating tumors, and comprehensive gene expression analyses have identified C-ion- or X-ray-specific gene expression profiles. However, no detailed miRNA expression analysis after C-ion irradiation has been reported. We recently demonstrated X-ray irradiation-induced expression of selected miRNAs in the A549 cell line, which is derived from human non-small cell lung cancer (NSCLC). One of these miRNAs, miR-574-3p, has been implicated in suppressing the enhancer of rudimentary homolog (ERH) gene, which has a role in cell cycle control. This study examined C-ion induced expression of miRNAs in the A549 cell line. We found that four miRNA molecules were induced by 1 Gy of C-ion irradiation, compared to 2 Gy of X-ray irradiation needed for the same result. These data suggested that these four miRNA genes use common transcriptional machinery in responding to both X-ray and C-ion irradiation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | BMB2010 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-12-10 | |||||
| 日付タイプ | Issued | |||||
