{"created":"2023-05-15T14:51:28.393244+00:00","id":70362,"links":{},"metadata":{"_buckets":{"deposit":"fd34be27-a829-4f60-a708-cc2742bedcba"},"_deposit":{"created_by":1,"id":"70362","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70362"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070362","sets":["10:28"]},"author_link":["690924","690927","690921","690925","690926","690922","690923","690928"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-12-10","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Changes in microRNA (miRNA) expression in response to photon irradiation have been analyzed in a variety of cell lines including cells derived from breast, lung, prostate, and oral cancers. Several different miRNAs were responsive to the irradiation. Interestingly, individual miRNA species showing a response in specific cell types were not identified in other cells. These previous studies therefore suggested that selected miRNAs are regulated in a cell- or tumor-specific manner.<BR>C-ions with high energy transfer (LET) have a major big advantage over X-rays in treating tumors, and comprehensive gene expression analyses have identified C-ion- or X-ray-specific gene expression profiles. However, no detailed miRNA expression analysis after C-ion irradiation has been reported.  We recently demonstrated X-ray irradiation-induced expression of selected miRNAs in the A549 cell line, which is derived from human non-small cell lung cancer (NSCLC). One of these miRNAs, miR-574-3p, has been implicated in suppressing the enhancer of rudimentary homolog (ERH) gene, which has a role in cell cycle control.  This study examined C-ion induced expression of miRNAs in the A549 cell line. We found that four miRNA molecules were induced by 1 Gy of C-ion irradiation, compared to 2 Gy of X-ray irradiation needed for the same result. These data suggested that these four miRNA genes use common transcriptional machinery in responding to both X-ray and C-ion irradiation.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"BMB2010","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishikawa, Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"690921","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Atsuko"}],"nameIdentifiers":[{"nameIdentifier":"690922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shoji, Yoshimi"}],"nameIdentifiers":[{"nameIdentifier":"690923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"690924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 顕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"690925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 敦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"690926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荘司 好美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"690927","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"690928","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Expression profiles of miRNA in A549 cell line exposed to carbon ion irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression profiles of miRNA in A549 cell line exposed to carbon ion irradiation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-12-13"},"publish_date":"2010-12-13","publish_status":"0","recid":"70362","relation_version_is_last":true,"title":["Expression profiles of miRNA in A549 cell line exposed to carbon ion irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:03:49.206895+00:00"}