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Invasive potential of pancreatic cell line, MIAPaCa-2, was affected by irradiation
https://repo.qst.go.jp/records/70268
https://repo.qst.go.jp/records/702683ec3caef-754a-480c-a419-04e257223382
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-10-01 | |||||
| タイトル | ||||||
| タイトル | Invasive potential of pancreatic cell line, MIAPaCa-2, was affected by irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujita, Mayumi
× Fujita, Mayumi× Yamada, Shigeru× Iwakawa, Mayumi× Imai, Takashi× 藤田 真由美× 山田 滋× 岩川 眞由美× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Pancreatic cancer is one of the most aggressive diseases with an extremely low 5-year survival rate, and shows inherent resistance to conventional chemotherapy and radiotherapy. Carbon-ion (C-ion) irradiation has advantages with accurate dose distribution and higher tumor cell killing. To compare the effects of X-ray and C-ion irradiation on the invasive potential of MIAPaCa-2, the cells were irradiated with either X-ray (0, 2, or 4 Gy) or C-ion (0, 0.5, 1, 2, or 4 Gy), and examined the migration, invasion, MMP expression and invasiveness in response to MMP inhibitors and/or ROCK inhibitors. X-ray irradiation stimulated invasiveness and induced MMP2 expression. In contrast, C-ion irradiation suppressed invasiveness without induction of MMP-2. Treatment of cells with MMP inhibitor, GM6001, reduced X-ray-induced invasiveness, but did not reduce the basal level of invasiveness. Analysis of cellular morphology showed inter-convertible mesenchymal and amoeboid modes, which may limit the effectiveness of single inhibitor. The use of ROCK inhibitor, Y27632, in addition to GM6001, reduced both the X-ray-induced and basal invasiveness. C-ion irradiation suppressed invasiveness much more than these inhibitors. In conclusion, C-ion irradiation gives higher efficiencies compared to X-ray irradiation in diminishing the invasive potential of MIAPaCa-2 cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 69th Annual Meeting of Japanese Cancer Association | |||||
| 発表年月日 | ||||||
| 日付 | 2010-09-24 | |||||
| 日付タイプ | Issued | |||||
