{"created":"2023-05-15T14:51:24.080612+00:00","id":70268,"links":{},"metadata":{"_buckets":{"deposit":"941bfce4-b2ff-40e3-be1b-0620e84b1dd9"},"_deposit":{"created_by":1,"id":"70268","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70268"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070268","sets":["10:28"]},"author_link":["689916","689917","689918","689915","689914","689920","689921","689919"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-09-24","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Pancreatic cancer is one of the most aggressive diseases with an extremely low 5-year survival rate, and shows inherent resistance to conventional chemotherapy and radiotherapy. Carbon-ion (C-ion) irradiation has advantages with accurate dose distribution and higher tumor cell killing. To compare the effects of X-ray and C-ion irradiation on the invasive potential of MIAPaCa-2, the cells were irradiated with either X-ray (0, 2, or 4 Gy) or C-ion (0, 0.5, 1, 2, or 4 Gy), and examined the migration, invasion, MMP expression and invasiveness in response to MMP inhibitors and/or ROCK inhibitors. X-ray irradiation stimulated invasiveness and induced MMP2 expression. In contrast, C-ion irradiation suppressed invasiveness without induction of MMP-2. Treatment of cells with MMP inhibitor, GM6001, reduced X-ray-induced invasiveness, but did not reduce the basal level of invasiveness. Analysis of cellular morphology showed inter-convertible mesenchymal and amoeboid modes, which may limit the effectiveness of single inhibitor. The use of ROCK inhibitor, Y27632, in addition to GM6001, reduced both the X-ray-induced and basal invasiveness. C-ion irradiation suppressed invasiveness much more than these inhibitors. In conclusion, C-ion irradiation gives higher efficiencies compared to X-ray irradiation in diminishing the invasive potential of MIAPaCa-2 cells.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"69th Annual Meeting of Japanese Cancer Association","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujita, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"689914","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"689915","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"689916","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"689917","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 真由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"689918","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"689919","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"689920","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"689921","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Invasive potential of pancreatic cell line, MIAPaCa-2, was affected by irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Invasive potential of pancreatic cell line, MIAPaCa-2, was affected by irradiation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-10-01"},"publish_date":"2010-10-01","publish_status":"0","recid":"70268","relation_version_is_last":true,"title":["Invasive potential of pancreatic cell line, MIAPaCa-2, was affected by irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:04:54.924302+00:00"}