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Age dependence of radiation-induced liver tumor of mice
https://repo.qst.go.jp/records/70257
https://repo.qst.go.jp/records/70257f7ce133b-06b7-4f63-b97e-5e48f3c9f100
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-09-28 | |||||
| タイトル | ||||||
| タイトル | Age dependence of radiation-induced liver tumor of mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shang, Yi
× Shang, Yi× Kakinuma, Shizuko× Kokubo, Toshiaki× Shimada, Yoshiya× 尚 奕× 柿沼 志津子× 小久保 年章× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The most significant risk of radiation is cancer development, resulting in the increase in age-specific mortality and the shortening of life expectancy. In order to estimate age dependence of susceptibility to radiation carcinogenesis, B6C3F1 mice were irradiated on 17 days post-conception (late fetal), 7 or 49 days post-parturition (neonatal or adult) with 2.0 or 4.0 Gy of gamma-rays. All mice were allowed to live throughout their entire life spans, and examined histologically for cancer spectrum at death. Mice in the neonatal period were most susceptible to radiation-induced liver tumor with the incidence up to 70% and significant life span shortening. To resolve the mechanism of age dependence, we examined the response of mouse liver to radiation from 0 to 48 hours after whole-body exposure to 4.0 Gy of gamma-rays. The results suggest that responses of neonatal hepatocytes to radiation, such as sustained proliferation and low apoptosis, differed from those of both fetal and adult hepatocytes. This difference may, at least in part, contribute to age dependent difference of the susceptibility to hepatocarcinogenesis. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 69th Annual Meeting of the Japanese Cancer Association | |||||
| 発表年月日 | ||||||
| 日付 | 2010-09-24 | |||||
| 日付タイプ | Issued | |||||
