@misc{oai:repo.qst.go.jp:00070257,
 author = {Shang, Yi and Kakinuma, Shizuko and Kokubo, Toshiaki and Shimada, Yoshiya and 尚 奕 and 柿沼 志津子 and 小久保 年章 and 島田 義也},
 month = {Sep},
 note = {The most significant risk of radiation is cancer development, resulting in the increase in age-specific mortality and the shortening of life expectancy. In order to estimate age dependence of susceptibility to radiation carcinogenesis, B6C3F1 mice were irradiated on 17 days post-conception (late fetal), 7 or 49 days post-parturition (neonatal or adult) with 2.0 or 4.0 Gy of gamma-rays. All mice were allowed to live throughout their entire life spans, and examined histologically for cancer spectrum at death. Mice in the neonatal period were most susceptible to radiation-induced liver tumor with the incidence up to 70% and significant life span shortening. To resolve the mechanism of age dependence, we examined the response of mouse liver to radiation from 0 to 48 hours after whole-body exposure to 4.0 Gy of gamma-rays. The results suggest that responses of neonatal hepatocytes to radiation, such as sustained proliferation and low apoptosis, differed from those of both fetal and adult hepatocytes. This difference may, at least in part, contribute to age dependent difference of the susceptibility to hepatocarcinogenesis., 69th Annual Meeting of the Japanese Cancer Association},
 title = {Age dependence of radiation-induced liver tumor of mice},
 year = {2010}
}