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Potential of hair root cells for dose estimation in partial body exposure
https://repo.qst.go.jp/records/70055
https://repo.qst.go.jp/records/700552a5440ca-5ecf-4d5f-8c10-974c98593d85
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-15 | |||||
| タイトル | ||||||
| タイトル | Potential of hair root cells for dose estimation in partial body exposure | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takashima, Yoshio
× Takashima, Yoshio× Nakata, Akifumi× Takada, Misaki× Akiyma, Miho× Yoshida, Mitsuaki× 高島 良生× 中田 章史× 川崎 実佐紀× 穐山 美穂× 吉田 光明 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Accidental radiation exposure should be estimated as accurately as practicable. This aids physicians in deciding the appropriate medical procedures. Chromosomal aberrations in the peripheral lymphocytes are the most reliable indicators for biological dose estimation. The conventional method for estimating this dose uses score marker aberrations, such as dicentric and ring chromosomes in lymphocytes. However, because lymphocytes circulate in the peripheral blood, the dose estimated from these dicentric or ring values is the mean dose of whole-body cumulative radiation exposure. Therefore, in the case of partial body exposure, it is difficult to estimate the partial dose of radiation by this method. It is necessary to use the partial organ in order to estimate the dose of partial body exposure. The aim of this study is to establish an assay system to evaluate the dose of partial body exposure. For this purpose, we used the human hair root as the target organ and detected the indicators of dose estimation; further, we examined the method of culturing hair root cells for detecting chromosomal aberrations. The epilated hairs were dissected carefully, and single cells were isolated enzymatically. When the hair was irradiated with gamma radiation, DNA damage was detectable in the comet assay, and the cultured hair root cells were grown in vitro. These results suggest that dose estimation of partial body exposure is possible using hair root cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | BioDose 2008 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-09-10 | |||||
| 日付タイプ | Issued | |||||
