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A Phase I/II Clinical Trial of Carbon-ion Therapy for patients with preoperative pancreas cancer (Protocol 9906, 16fractions/4weeks)
https://repo.qst.go.jp/records/70026
https://repo.qst.go.jp/records/70026ba540c42-9a34-4c23-87d7-e9a1fd06dca7
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-01-29 | |||||
| タイトル | ||||||
| タイトル | A Phase I/II Clinical Trial of Carbon-ion Therapy for patients with preoperative pancreas cancer (Protocol 9906, 16fractions/4weeks) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shinoto, Makoto
× Shinoto, Makoto× Yamada, Shigeru× Katou, Hirotoshi× Yasuda, Shigeo× Imada, Hiroshi× Kamada, Tadashi× Tsujii, Hirohiko× Saisho, Hiromitsu× 篠藤 誠× 山田 滋× 加藤 博敏× 安田 茂雄× 今田 浩史× 鎌田 正× 辻井 博彦× 税所 宏光 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: We examined the effect of preoperative carbon ion therapy in terms of reducing the rate of local recurrence in patients undergoing resection for adenocarcinoma of the pancreas. Patients and Methods: Between July 2000 and December 2002, 22 patients with preoperative pancreas cancer were enrolled into this trial. Median age was 63 years. Carbon ion therapy was given once daily, 4 days a week, for a fixed 16 fractions in 4 weeks. The dose was set to 44.8GyE and escalated to 48.0GyE at 5% increments. Results:All patients completed the scheduled treatment course. Three grade3 acute reactions and two grade3 late reactions occurred among 16 of the patients treated with a dose of 48.0GyE. Two grade 3 late reactions of them were estimated to be caused by carbon ion therapy. Of 22 patients, 15(68%) had resection. All tumor specimens pathologically revealed evidence of grade 2 treatment effects with significant fibrosis, hyalinization, and necrosis (Pathological grade2 is defined as a less than 33% active cancer cells.). Remarkable antitumor effects were observed. The overall local control rates were 100% and 87% at 1 year and at 2 years of follow-up respectively. No local failure was observed in any of the 22 enrolled patients. Conclusion: Carbon ion radiotherapy seems to be a safe and effective modality in the management of resectable pancreatic carcinoma, providing good local control and offering a survival advantage without unacceptable morbidity. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2010 Gastrointestinal Cancers Symposium | |||||
| 発表年月日 | ||||||
| 日付 | 2010-01-24 | |||||
| 日付タイプ | Issued | |||||
