{"created":"2023-05-15T14:51:13.504182+00:00","id":70026,"links":{},"metadata":{"_buckets":{"deposit":"f296d03d-90f0-4040-8586-3a039d1e9c7b"},"_deposit":{"created_by":1,"id":"70026","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70026"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070026","sets":["10:28"]},"author_link":["687574","687570","687572","687582","687568","687573","687577","687581","687576","687578","687579","687580","687569","687567","687571","687575"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-01-24","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: We examined the effect of preoperative carbon ion therapy in terms of reducing the rate of local recurrence in patients undergoing resection for adenocarcinoma of the pancreas.\nPatients and Methods:  Between July 2000 and December 2002, 22 patients with preoperative pancreas cancer were enrolled into this trial. Median age was 63 years. Carbon ion therapy was given once daily, 4 days a week, for a fixed 16 fractions in 4 weeks. The dose was set to 44.8GyE and escalated to 48.0GyE at 5% increments. \nResults:All patients completed the scheduled treatment course. Three grade3 acute reactions and two grade3 late reactions occurred among 16 of the patients treated with a dose of 48.0GyE. Two grade 3 late reactions of them were estimated to be caused by carbon ion therapy. Of 22 patients, 15(68%) had resection. All tumor specimens pathologically revealed evidence of grade 2 treatment effects with significant fibrosis, hyalinization, and necrosis (Pathological grade2 is defined as a less than 33% active cancer cells.).  Remarkable antitumor effects were observed. The overall local control rates were 100% and 87% at 1 year and at 2 years of follow-up respectively. No local failure was observed in any of the 22 enrolled patients.\nConclusion: Carbon ion radiotherapy seems to be a safe and effective modality in the management of resectable pancreatic carcinoma, providing good local control and offering a survival advantage without unacceptable morbidity.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"2010 Gastrointestinal Cancers Symposium","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shinoto, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"687567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"687568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katou, Hirotoshi"}],"nameIdentifiers":[{"nameIdentifier":"687569","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Shigeo"}],"nameIdentifiers":[{"nameIdentifier":"687570","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imada, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"687571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"687572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"687573","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saisho, Hiromitsu"}],"nameIdentifiers":[{"nameIdentifier":"687574","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠藤 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687575","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687576","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 博敏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687577","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 茂雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今田 浩史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687580","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"税所 宏光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687582","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"A Phase I/II Clinical Trial of Carbon-ion Therapy for patients with preoperative pancreas cancer (Protocol 9906, 16fractions/4weeks)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Phase I/II Clinical Trial of Carbon-ion Therapy for patients with preoperative pancreas cancer (Protocol 9906, 16fractions/4weeks)"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-01-29"},"publish_date":"2010-01-29","publish_status":"0","recid":"70026","relation_version_is_last":true,"title":["A Phase I/II Clinical Trial of Carbon-ion Therapy for patients with preoperative pancreas cancer (Protocol 9906, 16fractions/4weeks)"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:07:41.407020+00:00"}