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Actin-binding protein, VIL1, in cervical adenocarcinomas
https://repo.qst.go.jp/records/69998
https://repo.qst.go.jp/records/6999806a9e636-e00b-434b-b675-71c063bc53b5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-12-15 | |||||
| タイトル | ||||||
| タイトル | Actin-binding protein, VIL1, in cervical adenocarcinomas | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakamura, Etsuko
× Nakamura, Etsuko× Iwakawa, Mayumi× Nakawatari, Miyako× Imadome, Kaori× Imai, Takashi× 中村 悦子× 岩川 眞由美× 中渡 美也子× 今留 香織× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Villin1 (VIL1), a major structural component of the brush border cytoskeleton, binds actin in a calcium-dependent manner and has been reported as a marker for colon cancers. VIL1 was recently found to be an epithelial cell-specific anti-apoptotic protein and to have an important function in regulating actin dynamics, cell morphology, epithelial-to-mesenchymal transition, cell migration and cell survival. \nPurpose: We investigated a novel molecular biomarker for cervical adenocarcinoma (AD) through the integration of multiple methods of genomic analysis. Materials and Methods: Tumor samples in discovery set were obtained from 87 patients who underwent radiotherapy, including 31 cervical AD. Microarray analysis and quantitative polymerase chain reaction analysis were performed to screen a candidate diagnostic molecule for cervical AD, and its clinical significance was investigated by immunohistochemical analysis (IHC). Results: We analyzed the expression profiles of genes mapping to common deletious region in cervical cancer, and identified several consistently down-regulated genes, including ERBB4, VIL1, and DES in squamous cell carcinoma (SCC). Furthermore, we found a difference between biopsy samples of AD and SCC in the expression and genomic copy number of VIL1, which maps to 2q35. IHC revealed 14 VIL1-positive tumors; 13 cervical AD and 1 small cell carcinoma of cervix, while none of SCC or endometrial AD was VIL1-positive. The marker was validated by newly enrolled 65 patients, and VIL1 positive staining showed 52% of sensitivity and 100% of selectivity for cervical AD. In conclusion, we have identified VIL1 as a novel biomarker of cervical AD. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 32nd Annual Meeting of the Molecular Biology Society of Japan | |||||
| 発表年月日 | ||||||
| 日付 | 2009-12-12 | |||||
| 日付タイプ | Issued | |||||
