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子宮頸癌における分子診断マーカー、EpCAM
https://repo.qst.go.jp/records/69997
https://repo.qst.go.jp/records/69997b1bd77be-7921-4024-b384-4ef319b09331
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-12-15 | |||||
| タイトル | ||||||
| タイトル | 子宮頸癌における分子診断マーカー、EpCAM | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
今留, 香織
× 今留, 香織× 岩川, 眞由美× 中渡, 美也子× 中村, 悦子× 今井, 高志× 今留 香織× 岩川 眞由美× 中渡 美也子× 中村 悦子× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | [Objectives] To establish a novel molecular classification of cervical cancer, we investigated intrinsic characteristics using expression profile. [Patients and methods] We recruited pre-treatment biopsy samples of 143 patients. We designed 3 sets of patients to confirm our findings by microarray analysis. Immunohisochemical analysis (IHA) were also performed. [Results] The patients who all underwent radiotherapy. The statistical analysis for microarray data of 36 samples in 1st set formed mainly two clusters. Statistical test revealed 76 genes. Expression data of six representative genes, such as CK5, Nectin-1, CIDEB, AK091113.1 (SCC-type; up), TMEM98 and TACSTD1/EpCAM (AD; up) were confirmed by RT-PCR. IHA of EpCAM had strong positive immunoreactivity in AD (specificity; 90%, sensitivity; 80%), and its positive finding was related with prognosis (p = 0.048). [Conclusion] In this study, we report one of the most promising marker closely related with pathological diagnosis, EpCAM. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第32回日本分子生物学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-12-12 | |||||
| 日付タイプ | Issued | |||||
