WEKO3
アイテム
Modification of mortality and tumorigenesis by a water-soluble vitamin E analog, tocopherol-mono-glucoside (TMG)
https://repo.qst.go.jp/records/69968
https://repo.qst.go.jp/records/69968f64eddba-99a5-43a4-9bd0-d0946970bdd4
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-11-24 | |||||
| タイトル | ||||||
| タイトル | Modification of mortality and tumorigenesis by a water-soluble vitamin E analog, tocopherol-mono-glucoside (TMG) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Anzai, Kazunori
× Anzai, Kazunori× Ueno, Megumi× Inano, Hiroshi× Onoda, Makoto× Ikota, Nobuo× Kagiya, Tsutomu× et.al× 安西 和紀× 上野 恵美× 稲野 宏志× 小野田 眞 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of TMG administered post-irradiation on the mortality of X-irradiated mice and on the development of tumors in the mammary and pituitary glands in rats, was investigated. When TMG (650 mg/kg) was administered i.p. to mice immediately after 7 Gy of whole-body X-irradiation, the 30-day survival rate was significantly higher than that of control. The administration of TMG even at 4 h after irradiation significantly improved survival compared to that of control. When dams of lactating rats were exposed to 1.5 Gy X-rays at day 21 after parturition and treated with diethylstilbestrol as a tumor promoter, the incidence of mammary and pituitary tumors was increased compared to non-irradiated control. The administration of TMG (600 mg/kg, i.p.) after irradiation significantly reduced the incidence of mammary and pituitary tumors. These results suggest that TMG is effective in preventing radiation-induced bone marrow death in mice and in reducing mammary and pituitary tumors in rats even when administered after irradiation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | SFRBM's 16th Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2009-11-22 | |||||
| 日付タイプ | Issued | |||||
