@misc{oai:repo.qst.go.jp:00069968, author = {Anzai, Kazunori and Ueno, Megumi and Inano, Hiroshi and Onoda, Makoto and Ikota, Nobuo and Kagiya, Tsutomu and et.al and 安西 和紀 and 上野 恵美 and 稲野 宏志 and 小野田 眞}, month = {Nov}, note = {The effects of TMG administered post-irradiation on the mortality of X-irradiated mice and on the development of tumors in the mammary and pituitary glands in rats, was investigated. When TMG (650 mg/kg) was administered i.p. to mice immediately after 7 Gy of whole-body X-irradiation, the 30-day survival rate was significantly higher than that of control. The administration of TMG even at 4 h after irradiation significantly improved survival compared to that of control. When dams of lactating rats were exposed to 1.5 Gy X-rays at day 21 after parturition and treated with diethylstilbestrol as a tumor promoter, the incidence of mammary and pituitary tumors was increased compared to non-irradiated control. The administration of TMG (600 mg/kg, i.p.) after irradiation significantly reduced the incidence of mammary and pituitary tumors. These results suggest that TMG is effective in preventing radiation-induced bone marrow death in mice and in reducing mammary and pituitary tumors in rats even when administered after irradiation., SFRBM's 16th Annual Meeting}, title = {Modification of mortality and tumorigenesis by a water-soluble vitamin E analog, tocopherol-mono-glucoside (TMG)}, year = {2009} }