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A PHASE I/II CLINICAL TRIAL OF CARBON ION THERAPY FOR PATIENTS WITH LOCALLY ADVANCED PANCREAS CANCER (Protocol 0204, 12 fractions/3 weeks)
https://repo.qst.go.jp/records/69937
https://repo.qst.go.jp/records/69937e3070d16-ac43-4450-9c9e-3c8b6b00344e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-11-11 | |||||
| タイトル | ||||||
| タイトル | A PHASE I/II CLINICAL TRIAL OF CARBON ION THERAPY FOR PATIENTS WITH LOCALLY ADVANCED PANCREAS CANCER (Protocol 0204, 12 fractions/3 weeks) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shinoto, Makoto
× Shinoto, Makoto× Yamada, Shigeru× Katou, Hirotoshi× Yasuda, Shigeo× Imada, Hiroshi× Kamada, Tadashi× Tsujii, Hirohiko× Saisho, Hiromitsu× 篠藤 誠× 山田 滋× 加藤 博敏× 安田 茂雄× 今田 浩史× 鎌田 正× 辻井 博彦× 税所 宏光 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: We examined the maximum-tolerated dose and effect of carbon ion therapy alone for locally advanced pancreas cancer. Patients and Methods: Between April 2003 and February 2007, 46 patients with locally advanced pancreas cancer were eligible for this analysis. Patients eligible for study entry had histologically or cytologically confirmed with pancreas ductal adenocarcinoma. Carbon ion therapy was given once daily, 4 days a week, for fixed 12 fractions in 3 weeks. The dose was set at 38.4 GyE and escalated to 52.8 GyE at 5% increments. Results: Seven grade 3 acute and two grade 3 late toxicities were observed. Six of 7 grade 3 acute toxicities were anorexia. The maximum acute reaction of the grade 3 was observed in two-thirds of the patients (67%) on the 52.8 GyE. CR was observed in one lesion, PR in 7, SD in 37. The local control rate at one year in the all patients and in the patients receiving 45.6 GyE or more was 76% and 95% and the overall survival rate was 44% and 73%, respectively. Conclusion: Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally advanced pancreas cancer, providing good local control and offering a survival advantage without unacceptable morbidity. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 40ｔｈ Anniversary Meeting of APA and JPS | |||||
| 発表年月日 | ||||||
| 日付 | 2009-11-07 | |||||
| 日付タイプ | Issued | |||||
