@misc{oai:repo.qst.go.jp:00069937,
 author = {Shinoto, Makoto and Yamada, Shigeru and Katou, Hirotoshi and Yasuda, Shigeo and Imada, Hiroshi and Kamada, Tadashi and Tsujii, Hirohiko and Saisho, Hiromitsu and 篠藤 誠 and 山田 滋 and 加藤 博敏 and 安田 茂雄 and 今田 浩史 and 鎌田 正 and 辻井 博彦 and 税所 宏光},
 month = {Nov},
 note = {Purpose: We examined the maximum-tolerated dose and effect of carbon ion therapy alone for locally advanced pancreas cancer.
Patients and Methods: Between April 2003 and February 2007, 46 patients with locally advanced pancreas cancer were eligible for this analysis. Patients eligible for study entry had histologically or cytologically confirmed with pancreas ductal adenocarcinoma. Carbon ion therapy was given once daily, 4 days a week, for fixed 12 fractions in 3 weeks. The dose was set at 38.4 GyE and escalated to 52.8 GyE at 5% increments. 
Results: Seven grade 3 acute and two grade 3 late toxicities were observed. Six of 7 grade 3 acute toxicities were anorexia. The maximum acute reaction of the grade 3 was observed in two-thirds of the patients (67%) on the 52.8 GyE. CR was observed in one lesion, PR in 7, SD in 37. The local control rate at one year in the all patients and in the patients receiving 45.6 GyE or more was 76% and 95% and the overall survival rate was 44% and 73%, respectively.
Conclusion: Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally advanced pancreas cancer, providing good local control and offering a survival advantage without unacceptable morbidity., 40ｔｈ Anniversary Meeting of APA and JPS},
 title = {A PHASE I/II CLINICAL TRIAL OF CARBON ION THERAPY FOR PATIENTS WITH LOCALLY ADVANCED PANCREAS CANCER (Protocol 0204, 12 fractions/3 weeks)},
 year = {2009}
}