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FGF2 expression change as an acute radiotherapy responsive marker in sequential biopsy samples from cervical cancer patients during fractionated radiotherapy.

https://repo.qst.go.jp/records/69918
https://repo.qst.go.jp/records/69918
df688759-336f-4dfe-9a1c-36b84c11253a
Item type 会議発表用資料 / Presentation(1)
公開日 2009-10-27
タイトル
タイトル FGF2 expression change as an acute radiotherapy responsive marker in sequential biopsy samples from cervical cancer patients during fractionated radiotherapy.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Iwakawa, Mayumi

× Iwakawa, Mayumi

WEKO 686526

Iwakawa, Mayumi

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Nakawatari, Miyako

× Nakawatari, Miyako

WEKO 686527

Nakawatari, Miyako

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Imadome, Kaori

× Imadome, Kaori

WEKO 686528

Imadome, Kaori

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Ohno, Tatsuya

× Ohno, Tatsuya

WEKO 686529

Ohno, Tatsuya

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Kato, Shingo

× Kato, Shingo

WEKO 686530

Kato, Shingo

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Nakamura, Etsuko

× Nakamura, Etsuko

WEKO 686531

Nakamura, Etsuko

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Sakai, Minako

× Sakai, Minako

WEKO 686532

Sakai, Minako

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Ohkubo, Yu

× Ohkubo, Yu

WEKO 686533

Ohkubo, Yu

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Tamaki, Tomoaki

× Tamaki, Tomoaki

WEKO 686534

Tamaki, Tomoaki

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Imai, Takashi

× Imai, Takashi

WEKO 686535

Imai, Takashi

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岩川 眞由美

× 岩川 眞由美

WEKO 686536

en 岩川 眞由美

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中渡 美也子

× 中渡 美也子

WEKO 686537

en 中渡 美也子

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今留 香織

× 今留 香織

WEKO 686538

en 今留 香織

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大野 達也

× 大野 達也

WEKO 686539

en 大野 達也

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加藤 眞吾

× 加藤 眞吾

WEKO 686540

en 加藤 眞吾

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中村 悦子

× 中村 悦子

WEKO 686541

en 中村 悦子

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酒井 美奈子

× 酒井 美奈子

WEKO 686542

en 酒井 美奈子

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大久保 悠

× 大久保 悠

WEKO 686543

en 大久保 悠

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田巻 倫明

× 田巻 倫明

WEKO 686544

en 田巻 倫明

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今井 高志

× 今井 高志

WEKO 686545

en 今井 高志

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抄録
内容記述タイプ Abstract
内容記述 Purpose
Tumor microenvironment possesses extreamly important role for tumor progression and metastasis. Cytokines have autocrine and paracrine functions, and they are also secreted by normal and cancerous cells. Herewith we investigated an indicator for the efficacy of radiotherapy in cervical cancers (CC) using microarray analysis and immunohistochemical analysis.
Patients and methods
One hundred and four patients with CC were recruited and divided into two groups (research set: n =35, and validation set: n =69). Microarray analysis was performed in research set and further immunohistochemical analysis (IHA) was performed for all patients to detect candidate radioresponsive markers using pre-radiotherapy and mid-radiotherapy biopsy samples, which were taken one week after initiation of radiotherapy.
Results
FGF2 in tumor cells (FGF2–T) significantly increased in midtreatment samples compared with pretreatment samples in research set of patients, and the ratio change of FGF2-T was significantly related with better prognosis. This evidence was confirmed in validation set. Next using all 104 patimets we found IHA positive FGF2 in stromal cells (FGF2-S) in 85 patients, and the radiotherapy-induced increase of FGF-S in 23 patients. Though positive FGF2-S in pretreatment samples was significantly related with increased expression change of VEGF, it was not related with poor prognosis.
Conclusion
Radiation causes severing the normal or cancerous associations with adjacent cells and changes the extracellular matrix environment. Therefore, we need to investigate not only pretreatment status of tumors, but also modified tumor structures during fractionated radiotherapy. In this study, we found FGF2-T expression change as a monitoring marker for the effectiveness of radiotherapy, and found the relationship between FGF2-S in pretreatment status and VEGF expression change in a subgroup of patients.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 5th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention
発表年月日
日付 2009-10-24
日付タイプ Issued
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