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Evaluation of Bone Marrow Activity after Carbon-Ion Radiotherapy by PET/CT Using a Proliferative Tracer, FLT
https://repo.qst.go.jp/records/69909
https://repo.qst.go.jp/records/69909f1779cf5-769f-4258-9939-e07f8a0a2000
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-23 | |||||
| タイトル | ||||||
| タイトル | Evaluation of Bone Marrow Activity after Carbon-Ion Radiotherapy by PET/CT Using a Proliferative Tracer, FLT | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koizumi, Mitsuru
× Koizumi, Mitsuru× Saga, Tsuneo× Inubushi, Masayuki× Yoshikawa, Kyosan× Fukumura, Toshimitsu× Baba, Masayuki× 小泉 満× 佐賀 恒夫× 犬伏 正幸× 吉川 京燦× 福村 利光× 馬場 雅行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim: In the radiation therapy, normal bone marrow is often included in radiation field inevitably. The aim of this study was to investigate the change in 3'-18F-fluoro-3'-deoxy-L-thymidine (FLT) uptake to normal bone marrow after inevitable radiation. Methods: Twenty-one non-small cell lung cancer (NSCLC) patients who received carbon ion radiotherapy (CIRT) were studied with regard to bone marrow activity by FLT PET/CT. CIRT was performed with three protocols (42-44 GyE/1 fraction in 9 patients, 52.8-60 GyE/4 fractions in 10 patients, and 62.8 GyE/12 fractions in 2 patients). These dose and fraction pairs gave the similar clinical tumor response results. Radiation dose to bone marrow was calculated by three dimensional CT planning system. FLT PET/CT studies were carried out before and after CIRT. Post-CIRT FLT studies were performed at 1 or 2 day after CIRT (6 patients), 3 months after CIRT (20 patients) and more than 1 year after CIRT (3 patients). FLT uptake was evaluated visually and by a maximum standard uptake value (SUVmax). In some evaluations, the ratio of uptake of irradiated marrow to non-irradiated counterpart was used. As non-irradiated control sites, changes in lumbar (L2-5) bone marrow FLT uptake were measured. Irradiated bone marrow was divided into 2 two groups (10-30 % of maximum dose, and more than 30% of maximum dose), and the changes of FLT uptake were measured. Results: Ribs were included in the radiation field in all patients; spine in 2 patients, scapula in 7 patients, and sternum in 2 patients. FLT uptake in the bone marrow receiving the 10 % dose or more clearly decreased at all time points after CIRT in comparison with pre-irradiation values. The FLT uptake was the lowest just after CIRT, somewhat recovered at 3 months, and remained unchanged for more than 1 year. There was no significant difference in reduction of FLT uptake between the area receiving 10-30% dose and those receiving more than 30%. FLT uptake to non-irradiated areas (L2-5) was not changed after CIRT. Conclusion: Bone marrow receiving as low as 10% dose of carbon ion showed clearly decreased FLT uptake. Bone marrow cells are considered sensitive to low dose. FLT-PET can sensitively detect these changes and may help to confirm the radiation field. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Annual Congress of the European Association of Nuclear Medicine 2009 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-10-14 | |||||
| 日付タイプ | Issued | |||||
