{"created":"2023-05-15T14:51:08.415306+00:00","id":69909,"links":{},"metadata":{"_buckets":{"deposit":"6f0bf3fd-1691-4ccc-9e09-45430818e507"},"_deposit":{"created_by":1,"id":"69909","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69909"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069909","sets":["10:28"]},"author_link":["686429","686418","686420","686427","686425","686426","686421","686419","686424","686422","686428","686423"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-14","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: In the radiation therapy, normal bone marrow is often included in radiation field inevitably. The aim of this study was to investigate the change in 3'-18F-fluoro-3'-deoxy-L-thymidine (FLT) uptake to normal bone marrow after inevitable radiation.\nMethods: Twenty-one non-small cell lung cancer (NSCLC) patients who received carbon ion radiotherapy (CIRT) were studied with regard to bone marrow activity by FLT PET/CT. CIRT was performed with three protocols (42-44 GyE/1 fraction in 9 patients, 52.8-60 GyE/4 fractions in 10 patients, and 62.8 GyE/12 fractions in 2 patients). These dose and fraction pairs gave the similar clinical tumor response results. Radiation dose to bone marrow was calculated by three dimensional CT planning system. FLT PET/CT studies were carried out before and after CIRT. Post-CIRT FLT studies were performed at 1 or 2 day after CIRT (6 patients), 3 months after CIRT (20 patients) and more than 1 year after CIRT (3 patients). FLT uptake was evaluated visually and by a maximum standard uptake value (SUVmax). In some evaluations, the ratio of uptake of irradiated marrow to non-irradiated counterpart was used. As non-irradiated control sites, changes in lumbar (L2-5) bone marrow FLT uptake were measured. Irradiated bone marrow was divided into 2 two groups (10-30 % of maximum dose, and more than 30% of maximum dose), and the changes of FLT uptake were measured.\nResults: Ribs were included in the radiation field in all patients; spine in 2 patients, scapula in 7 patients, and sternum in 2 patients. FLT uptake in the bone marrow receiving the 10 % dose or more clearly decreased at all time points after CIRT in comparison with pre-irradiation values. The FLT uptake was the lowest just after CIRT, somewhat recovered at 3 months, and remained unchanged for more than 1 year. There was no significant difference in reduction of FLT uptake between the area receiving 10-30% dose and those receiving more than 30%. FLT uptake to non-irradiated areas (L2-5) was not changed after CIRT.\nConclusion: Bone marrow receiving as low as 10% dose of carbon ion showed clearly decreased FLT uptake. Bone marrow cells are considered sensitive to low dose. FLT-PET can sensitively detect these changes and may help to confirm the radiation field.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Annual Congress of the European Association of Nuclear Medicine 2009","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koizumi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"686418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"686419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inubushi, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"686420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshikawa, Kyosan"}],"nameIdentifiers":[{"nameIdentifier":"686421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumura, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"686422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Baba, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"686423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小泉 満","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"686424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"686425","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"犬伏 正幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"686426","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉川 京燦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"686427","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"686428","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬場 雅行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"686429","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Evaluation of Bone Marrow Activity after Carbon-Ion Radiotherapy by PET/CT Using a Proliferative Tracer, FLT","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of Bone Marrow Activity after Carbon-Ion Radiotherapy by PET/CT Using a Proliferative Tracer, FLT"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-23"},"publish_date":"2009-10-23","publish_status":"0","recid":"69909","relation_version_is_last":true,"title":["Evaluation of Bone Marrow Activity after Carbon-Ion Radiotherapy by PET/CT Using a Proliferative Tracer, FLT"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:09:02.380106+00:00"}