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Comparison of Glucose metabolism measured by FDG-PET/CT and Cellularity obtained from MRI for malignancy evaluation of pancreatic tumor
https://repo.qst.go.jp/records/69908
https://repo.qst.go.jp/records/69908a09a9e46-bc8f-4935-95c7-33225a5e4246
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-23 | |||||
| タイトル | ||||||
| タイトル | Comparison of Glucose metabolism measured by FDG-PET/CT and Cellularity obtained from MRI for malignancy evaluation of pancreatic tumor | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tanimoto, Katsuyuki
× Tanimoto, Katsuyuki× Yoshikawa, Kyosan× Obata, Takayuki× Toubaru, Sachiko× Ohashi, Seiya× Hasebe, Mitsuhiko× Shiraishi, Takahiro× Watanabe, Kazuhiro× Saga, Tsuneo× Ikehira, Hiroo× Mizoe, Junetsu× Kamada, Tadashi× Tsujii, Hirohiko× Miyazaki, Masaru× et.al× 谷本 克之× 吉川 京燦× 小畠 隆行× 桃原 幸子× 大橋 靖也× 長谷部 充彦× 白石 貴博× 渡邊 和洋× 佐賀 恒夫× 池平 博夫× 溝江 純悦× 鎌田 正× 辻井 博彦× 宮崎 勝 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives FDG-PET provides quantitative information about tumor glucose utilization witch is useful for clinical diagnosis of tumor diseases. Standardized Uptake Value (SUV) is most commonly used for evaluation of tumor glucose utilization. But, SUV is affected by many factors that cannot be controlled or even taken into account. In that respect, brain reference index (BRI: ROI of tumor / ROI of cerebellum) is one of the novel quantitative approaches to eliminating the variety of factors that affect SUV. Meanwhile, a MRI pulse sequence could reveal the information about tissue cellularity. This information is useful to evaluate tumor nature. It suggests that it can be useful in the evaluation of malignancy in the lesions. We compared the role of glucose metabolism and cellularity for detection of pancreatic tumor malignancy. Materials and Methods PET/CT: Toshiba Aquiduo, LSO crystals, 3D acquisition mode: 3min, OS-EM Iteration: 4, Subset: 14, Gaussian post filter: 8.0mm 16 Multidetector-row CT, 120kV, Automatic exposure control (160 effective mAs), Helical pitch: 15mm/rot. MRI: GE healthcare Signa HDx 3T Pre-surgery patients with primary pancreatic tumor underwent a whole body FDG-PET/CT and 3Tesla MRI. The malignancy or benignancy of excised specimens was pathologically confirmed in all cases. Tumor glucose utilization was evaluated with SUV and BRI in FDG-PET/CT study, and tumor cellularity was determined with MRI factors, apparent diffusion coefficient (ADC), T2 value and tumor to non-tumor ratio of proton density (TNRPD) in MRI study. ADC were measured with a diffusion weighted image (DWI) using a spin-echo echo-planar sequence (TR=10s; TE=80ms; b factor=0, 400, 800,1200s/mm2). T2 value and proton density were measured with a spin-echo sequence (TR=3s; TE=40, 60, 80, 100ms). We calculated TNRPD from proton density values of tumor and normal pancreas. We compared these results with pathological findings. Results FDG uptake tended to be higher in malignant tumor than benign tumor. BRI seemed to distinguish malignant lesions from benign lesions more clearly than SUV alone. ADC was lower in malignant tumor than benign tumor. Malignant tumors showed higher TNRPD than benign tumors. Conclusions The tumor that shows high SUV, high BRI, low ADC, high TNRPD, high T2WI and high DWI indicate a high probability of pancreatic tumor malignancy. FDG-PET/CT in combination with MRI was superior to each modality alone for evaluating tumor malignant nature. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 2009 EANM Congress | |||||
| 発表年月日 | ||||||
| 日付 | 2009-10-14 | |||||
| 日付タイプ | Issued | |||||
