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アイテム
TRANSCRIPTIONAL REGULATION OF Il9r IN RADIATION-INDUCED MOUSE T-CELL LEYKEMIA CELL LINE
https://repo.qst.go.jp/records/69888
https://repo.qst.go.jp/records/69888d8c58a8f-9b58-4742-a45d-b158668f6273
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-10 | |||||
| タイトル | ||||||
| タイトル | TRANSCRIPTIONAL REGULATION OF Il9r IN RADIATION-INDUCED MOUSE T-CELL LEYKEMIA CELL LINE | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shang, Yi
× Shang, Yi× Kakinuma, Shizuko× Shimada, Yoshiya× 尚 奕× 柿沼 志津子× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Interleukin-9 (IL-9) is a multifunctional cytokine secreted from Th2 cell. Besides its role in immune and inflammatory responses, its growth promoting and antiapoptotic activities on multiple transformed cells suggest a potential role in tumorigenesis. We previously reported over-expression and activation of the receptor of IL-9 (IL-9R) in radiation-induced mouse T-cell leukemia (TL), which is an animal model of human T-cell acute lymphoblastic leukemia. In this study we established an Il9r-highly-expressing TL cell line, and examined the promoter activity with luciferase reporter assay. We found that promoter regulatory region was located at a 5` AT-rich region from -410 bp to -487 bp upstream translation start codon. EMSA and ChIP assay were also carried out to investigate the associated transcription factor(s). | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 68th Annual Meeting of the Japanese Cancer Association | |||||
| 発表年月日 | ||||||
| 日付 | 2009-10-03 | |||||
| 日付タイプ | Issued | |||||
