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マウス胚性幹細胞由来神経幹細胞の増殖と維持に対するＸ線照射の影響
https://repo.qst.go.jp/records/69850
https://repo.qst.go.jp/records/69850fbe59bc0-cb80-4580-9ab3-d2e4cca5a7bb
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-09-15 | |||||
| タイトル | ||||||
| タイトル | マウス胚性幹細胞由来神経幹細胞の増殖と維持に対するＸ線照射の影響 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
磯野, 真由
× 磯野, 真由× 田邉, 利彰× 大津, 昌弘× 大谷, 浩樹× 福士, 政広× 中山, 孝× 井上, 順雄× 磯野 真由 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation exposure during the fetal period leads to disturbances in development of the brain and can induce microcephaly. It suggests that X-irradiation may affect proliferation of the neural stem cells during early neural development. Here we investigated the effects of the irradiation on the neural stem cells, prepared from mouse embryonic stem (ES) cells by the Neural Stem Sphere (NSS) method. The proliferation of the neural stem cells cultured with fibroblast growth factor-2 (FGF-2) was dose-dependently inhibited by X-irradiation. Although X-irradiation also induced process elongation of the cells in a dose-dependent manner, gene expression of the marker genes for the neural stem cells, nestin, musashi-1, was maintained. This work was partly supported by a grant of LRI by JCIA and Selective Research Fund of Tokyo Metropolitan University. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第31回日本神経科学会/Neuroscience2008 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-07-11 | |||||
| 日付タイプ | Issued | |||||
