@misc{oai:repo.qst.go.jp:00069850,
 author = {磯野, 真由 and 田邉, 利彰 and 大津, 昌弘 and 大谷, 浩樹 and 福士, 政広 and 中山, 孝 and 井上, 順雄 and 磯野 真由},
 month = {Jul},
 note = {Radiation exposure during the fetal period leads to disturbances in development of the brain and can induce microcephaly. It suggests that X-irradiation may affect proliferation of the neural stem cells during early neural development. Here we investigated the effects of the irradiation on the neural stem cells, prepared from mouse embryonic stem (ES) cells by the Neural Stem Sphere (NSS) method. The proliferation of the neural stem cells cultured with fibroblast growth factor-2 (FGF-2) was dose-dependently inhibited by X-irradiation. Although X-irradiation also induced process elongation of the cells in a dose-dependent manner, gene expression of the marker genes for the neural stem cells, nestin, musashi-1, was maintained. This work was partly supported by a grant of LRI by JCIA and Selective Research Fund of Tokyo Metropolitan University., 第31回日本神経科学会/Neuroscience2008},
 title = {マウス胚性幹細胞由来神経幹細胞の増殖と維持に対するＸ線照射の影響},
 year = {2008}
}