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Simplified Quantification of Adenosine A2A Receptor with [11C]TMSX PET and Graphical Analyses
https://repo.qst.go.jp/records/69797
https://repo.qst.go.jp/records/6979797b7e12b-2d2b-4a41-a8b7-3fea32cec984
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-07-13 | |||||
| タイトル | ||||||
| タイトル | Simplified Quantification of Adenosine A2A Receptor with [11C]TMSX PET and Graphical Analyses | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Naganawa, Mika
× Naganawa, Mika× Mishina, Masahiro× Sakata, Muneyuki× Oda, Keiichi× Ishii, Kenji× Ishiwata, Kiichi× Kimura, Yuichi× 長縄 美香× 坂田 宗之× 織田 圭一× 石井 賢二× 石渡 喜一× 木村 裕一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: [11C]TMSX is one of the few available radioligands to quantify adenosine A2A receptor (A2AR) [1]. Although A2ARs are rich in the basal ganglia and poor in other regions, [11C]TMSX binds to not only classical A2ARs but also atypical sites. Therefore, it is difficult to find a reference region. In previous studies with arterial input function, we selected the centrum semiovale (CSO) as a reference region [2,3]. The purpose of this study was to investigate the availability of graphical analyses for human [11C]TMSX studies with region of interest (ROI) analysis. \nMethods: Seven healthy subjects were included in this study. The average dose was 570 +- 86 MBq and the specific activity was 39 +- 21 GBq/µmol. Dynamic PET scans were acquired for 1 hour with a SET-2400W (Shimadzu, Japan). A total of 25 ROIs was manually delineated on the summed PET image: CSO (reference), anterior and posterior putamen, caudate, midbrain, posterior cingulate, cerebral cortical areas, and cerebellum. The regional time-activity curves (TACs) were analyzed using one- and two-tissue compartment models (1T, 2T), Logan graphical analysis (LGA) and multilinear analysis (MA1) with a metabolite-corrected input function. TACs were also analyzed using reference Logan graphical analysis (LGAR). The clearance rate constant of the reference region (k2') for LGAR was fixed to be 0.12 min-1, the mean value from the 1T model. For all graphical methods, t* was set to be 20 min post-injection. \nResults: Metabolism of [11C]TMSX was very slow with parent fraction of 0.98 +- 0.01 at 3 min and 0.92 +- 0.05 at 60 min. The ROIs were well described by 2T model with a constraint of VND from the 1T estimation of CSO. The values of VT ranged from 0.58 +- 0.16 (CSO) to 1.25 +- 0.29 mL/cm3 (anterior putamen), with K1 values of 0.068 +- 0.014 to 0.30 +- 0.07 mL/min/cm3. The estimated VT of graphical analyses and 2T matched well (VT(LGA) = 0.99 VT(2T) + 0.01 (r2 = 0.99), VT(MA1) = 1.01 VT(2T) + 0.01 (r2 = 0.99)). The estimated VT in CSO was 5% higher in graphical analyses than in 1T model. As a result, the estimated BPND of LGA and MA1 showed smaller values compared with compartment model analysis (BPND(2T) = 0.83BPND(MA1) + 0.06 (r2 = 0.92)). The LGAR provided similar results (BPND(LGAR) = 0.99BPND(MA1) - 0.01 (r2 = 0.99)). \nConclusions: All graphical analyses provided similar estimates of VT and BPND for ROI curves. This study suggests that LGAR is available for quantification of [11C]TMSX ROI analysis. The difference of BPND values in graphical analyses and compartment analysis is due to the estimates of VND value. The suitability of CSO as a reference region should be further investigated and the noise-reduction method is required for LGAR imaging. \nReferences: [1] Ishiwata K, et al. JNM, 41:345-354, 2000. [2] Naganawa M, et al. EJNM, 34:679-687, 2007. [3] Svenningsson P, et al. Synapse, 27:322-335, 1997. Acknowledgments: This work was funded by Grants-in-Aid for Scientific Research (B) No. 16390348, (C) No. 17590901 and No. 20591033 from JSPS. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Brain'09 & BrainPET'09 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-07-03 | |||||
| 日付タイプ | Issued | |||||
