{"created":"2023-05-15T14:51:03.519153+00:00","id":69797,"links":{},"metadata":{"_buckets":{"deposit":"6c792d9a-b7e8-4379-9614-0ccd11034c5f"},"_deposit":{"created_by":1,"id":"69797","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69797"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069797","sets":["10:28"]},"author_link":["685304","685293","685300","685297","685296","685294","685298","685292","685303","685295","685301","685299","685302"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-07-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: [11C]TMSX is one of the few available radioligands to quantify adenosine A2A receptor (A2AR) [1]. Although A2ARs are rich in the basal ganglia and poor in other regions, [11C]TMSX binds to not only classical A2ARs but also atypical sites. Therefore, it is difficult to find a reference region. In previous studies with arterial input function, we selected the centrum semiovale (CSO) as a reference region [2,3]. The purpose of this study was to investigate the availability of graphical analyses for human [11C]TMSX studies with region of interest (ROI) analysis.\n\\nMethods: Seven healthy subjects were included in this study. The average dose was 570 +- 86 MBq and the specific activity was 39 +- 21 GBq/µmol. Dynamic PET scans were acquired for 1 hour with a SET-2400W (Shimadzu, Japan). A total of 25 ROIs was manually delineated on the summed PET image: CSO (reference), anterior and posterior putamen, caudate, midbrain, posterior cingulate, cerebral cortical areas, and cerebellum. The regional time-activity curves (TACs) were analyzed using one- and two-tissue compartment models (1T, 2T), Logan graphical analysis (LGA) and multilinear analysis (MA1) with a metabolite-corrected input function. TACs were also analyzed using reference Logan graphical analysis (LGAR). The clearance rate constant of the reference region (k2') for LGAR was fixed to be 0.12 min-1, the mean value from the 1T model. For all graphical methods, t* was set to be 20 min post-injection.\n\\nResults: Metabolism of [11C]TMSX was very slow with parent fraction of 0.98 +- 0.01 at 3 min and 0.92 +- 0.05 at 60 min. The ROIs were well described by 2T model with a constraint of VND from the 1T estimation of CSO. The values of VT ranged from 0.58 +- 0.16 (CSO) to 1.25 +- 0.29 mL/cm3 (anterior putamen), with K1 values of 0.068 +- 0.014 to 0.30 +- 0.07 mL/min/cm3. The estimated VT of graphical analyses and 2T matched well (VT(LGA) = 0.99 VT(2T) + 0.01 (r2 = 0.99), VT(MA1) = 1.01 VT(2T) + 0.01 (r2 = 0.99)). The estimated VT in CSO was 5% higher in graphical analyses than in 1T model. As a result, the estimated BPND of LGA and MA1 showed smaller values compared with compartment model analysis (BPND(2T) = 0.83BPND(MA1) + 0.06 (r2 = 0.92)). The LGAR provided similar results (BPND(LGAR) = 0.99BPND(MA1) - 0.01 (r2 = 0.99)).\n\\nConclusions: All graphical analyses provided similar estimates of VT and BPND for ROI curves. This study suggests that LGAR is available for quantification of [11C]TMSX ROI analysis. The difference of BPND values in graphical analyses and compartment analysis is due to the estimates of VND value. The suitability of CSO as a reference region should be further investigated and the noise-reduction method is required for LGAR imaging.\n\\nReferences:\n[1] Ishiwata K, et al. JNM, 41:345-354, 2000.\n[2] Naganawa M, et al. EJNM, 34:679-687, 2007.\n[3] Svenningsson P, et al. Synapse, 27:322-335, 1997.\nAcknowledgments: This work was funded by Grants-in-Aid for Scientific Research (B) No. 16390348, (C) No. 17590901 and No. 20591033 from JSPS.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Brain'09 & BrainPET'09","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naganawa, Mika"}],"nameIdentifiers":[{"nameIdentifier":"685292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mishina, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"685293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakata, Muneyuki"}],"nameIdentifiers":[{"nameIdentifier":"685294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oda, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"685295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"685296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiwata, Kiichi"}],"nameIdentifiers":[{"nameIdentifier":"685297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"685298","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長縄 美香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685299","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂田 宗之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685300","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"織田 圭一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685301","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井 賢二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685302","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石渡 喜一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685303","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685304","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Simplified Quantification of Adenosine A2A Receptor with [11C]TMSX PET and Graphical Analyses","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Simplified Quantification of Adenosine A2A Receptor with [11C]TMSX PET and Graphical Analyses"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-07-13"},"publish_date":"2009-07-13","publish_status":"0","recid":"69797","relation_version_is_last":true,"title":["Simplified Quantification of Adenosine A2A Receptor with [11C]TMSX PET and Graphical Analyses"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:10:18.700610+00:00"}