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Simplified Quantification of Adenosine A1 Receptor with [11C]MPDX and Graphical Analysis
https://repo.qst.go.jp/records/69780
https://repo.qst.go.jp/records/69780d6291946-8248-41c4-9ef8-73f2098541f3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-07-06 | |||||
| タイトル | ||||||
| タイトル | Simplified Quantification of Adenosine A1 Receptor with [11C]MPDX and Graphical Analysis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kimura, Yuichi
× Kimura, Yuichi× Naganawa, Mika× Mishina, Masahiro× Sakata, Muneyuki× Oda, Keiichi× Ishii, Kenji× Ishiwata, Kiichi× 木村 裕一× 長縄 美香× 坂田 宗之× 織田 圭一× 石井 賢二× 石渡 喜一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: [11C]MPDX is a clinically available radioligand for quantification of the adenosine A1 receptor (A1R) [1], and its kinetic analysis was reported in [2]. The purpose of this study was to investigate an applicability of simplified graphical algorithms for human studies based on ROI analysis. \nMethods: Six normal subjects were included in this study. The dose was 610+/-126 MBq, and the specific activity was 53+/-37 MBq/nmol. Dynamic PET scans were performed for 1 hour using SET-2400W (Shimadzu, Kyoto, Japan) in two-dimensional mode with arterial blood sampling. A total of 24 ROIs was placed manually on the summed images: cerebellum (reference), pons, midbrain, caudate, putamen, thalamus, posterior cingulate, and frontal, temporal, occipital, and parietal lobes. The ROI-averaged tissue time activity curves (tTACs) were analyzed using five algorithms: one- and two-tissue compartment models (1T and 2T), Logan graphical analysis (LGA), and a reference LGA with or without a clearance rate of a reference region (k2) (LGAR-k2 and LGARNok2)[3]. For LGAR-k2, the k2 in a reference region was derived from the cerebellum using 1T. All graphical analyses were applied after 20-minute post-injection. \nResults: The metabolism of [11C]MPDX was slow; the parent fraction was 0.74+-0.07 at 60 min after injection. The tTACs were well described using 2T with a constraint of VND that was estimated from the reference region using 1T. The values of VT and K1 ranged from 0.52+-0.11 (cerebellum) to 0.72+-0.13 mL/cm3 (posterior putamen) and from 0.10+-0.03 (cerebellum) to 0.13+-0.04 mL/min/cm3 (posterior putamen), respectively. The k2 in reference regions were (0.45+-0.11 min-1). The kinetics in reference regions was described using 1T model, and 2T fitting could not give us reasonable VND, VND(1T)=0.98*VND(LGA)-0.06 (r2=0.96). In the graphical analyses, BPND using the simplified algorithms of LGAR-k2 and LGAR-Nok2 matched well with those using LGA: BPND(LGAR-k2)= 0.99*BPND(LGA)+0.01 (r2=0.95) and BPND(LGAR-Nok2)= 0.96*BPND(LGA)-0.01(r2=0.94). \nConclusions: Both the simplified algorithms based on Logan graphical analysis without an arterial input function provided corresponding BPND with those of LGA using an input function in ROI-based analysis. These results implied that LGAR-Nok2 was applicable for the quantification of A1Rs using [11C]MPDX. \nReferences: [1] Ishiwata, et al., Ann Nucl Med, 16, 377-382, 2002. [2] Y Kimura, et al., Nucl Med Biol, 31, 975-981, 2004. [3] J Logan, et al., J Cereb Blood Flow Metabo, 16, 834-840, 1996. Acknowledgement: This work was supported by Grants-in-Aid for Scientific Research (B) No. 20390333,(B) 20390334 and (B) No. 16390348. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Brain'09 & BrainPET'09 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-07-03 | |||||
| 日付タイプ | Issued | |||||
