{"created":"2023-05-15T14:51:02.776805+00:00","id":69780,"links":{},"metadata":{"_buckets":{"deposit":"55785187-1573-4a7a-bb40-4af84f73edae"},"_deposit":{"created_by":1,"id":"69780","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69780"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069780","sets":["10:28"]},"author_link":["685087","685077","685084","685089","685083","685078","685080","685079","685082","685086","685085","685088","685081"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-07-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: [11C]MPDX is a clinically available radioligand for quantification of the adenosine A1 receptor (A1R) [1], and its kinetic analysis was reported in [2]. The purpose of this study was to investigate an applicability of simplified graphical algorithms for human studies based on ROI analysis.\n\\nMethods: Six normal subjects were included in this study. The dose was 610+/-126 MBq, and the specific activity was 53+/-37 MBq/nmol. Dynamic PET scans were performed for 1 hour using SET-2400W (Shimadzu, Kyoto, Japan) in two-dimensional mode with arterial blood sampling. A total of 24 ROIs was placed manually on the summed images: cerebellum (reference), pons, midbrain, caudate, putamen, thalamus, posterior cingulate, and frontal, temporal, occipital, and parietal lobes. The ROI-averaged tissue time activity curves (tTACs) were analyzed using five algorithms: one- and two-tissue compartment models (1T and 2T), Logan graphical analysis (LGA), and a reference LGA with or without a clearance rate of a reference region (k2) (LGAR-k2 and LGARNok2)[3]. For LGAR-k2, the k2 in a reference region was derived from the cerebellum using 1T. All graphical analyses were applied after 20-minute post-injection.\n\\nResults: The metabolism of [11C]MPDX was slow; the parent fraction was 0.74+-0.07 at 60 min after injection. The tTACs were well described using 2T with a constraint of VND that was estimated from the reference region using 1T. The values of VT and K1 ranged from 0.52+-0.11 (cerebellum) to 0.72+-0.13 mL/cm3 (posterior putamen) and from 0.10+-0.03 (cerebellum) to 0.13+-0.04 mL/min/cm3 (posterior putamen), respectively. The k2 in reference regions were (0.45+-0.11 min-1). The kinetics in reference regions was described using 1T model, and 2T fitting could not give us reasonable VND, VND(1T)=0.98*VND(LGA)-0.06 (r2=0.96). In the graphical analyses, BPND using the simplified algorithms of LGAR-k2 and LGAR-Nok2 matched well with those using LGA: BPND(LGAR-k2)= 0.99*BPND(LGA)+0.01 (r2=0.95) and BPND(LGAR-Nok2)= 0.96*BPND(LGA)-0.01(r2=0.94).\n\\nConclusions: Both the simplified algorithms based on Logan graphical analysis without an arterial input function provided corresponding BPND with those of LGA using an input function in ROI-based analysis. These results implied that LGAR-Nok2 was applicable for the quantification of A1Rs using [11C]MPDX.\n\\nReferences:\n[1] Ishiwata, et al., Ann Nucl Med, 16, 377-382, 2002.\n[2] Y Kimura, et al., Nucl Med Biol, 31, 975-981, 2004.\n[3] J Logan, et al., J Cereb Blood Flow Metabo, 16, 834-840, 1996.\nAcknowledgement: This work was supported by Grants-in-Aid for Scientific Research (B) No. 20390333,(B) 20390334 and (B) No. 16390348.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Brain'09 & BrainPET'09","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kimura, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"685077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naganawa, Mika"}],"nameIdentifiers":[{"nameIdentifier":"685078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mishina, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"685079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakata, Muneyuki"}],"nameIdentifiers":[{"nameIdentifier":"685080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oda, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"685081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"685082","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiwata, Kiichi"}],"nameIdentifiers":[{"nameIdentifier":"685083","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685084","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長縄 美香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685085","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂田 宗之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685086","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"織田 圭一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685087","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井 賢二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685088","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石渡 喜一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685089","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Simplified Quantification of Adenosine A1 Receptor with [11C]MPDX and Graphical Analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Simplified Quantification of Adenosine A1 Receptor with [11C]MPDX and Graphical Analysis"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-07-06"},"publish_date":"2009-07-06","publish_status":"0","recid":"69780","relation_version_is_last":true,"title":["Simplified Quantification of Adenosine A1 Receptor with [11C]MPDX and Graphical Analysis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:10:30.309741+00:00"}