WEKO3
アイテム
Heavy-Ion Irradiation Disrupts Cancer Stem Cells And Completely Controls Transplantable Human Colon Cancer In Nude Mice
https://repo.qst.go.jp/records/69753
https://repo.qst.go.jp/records/69753880a3fcf-1838-4ede-b9b8-be9e5bd1a62f
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-05-25 | |||||
| タイトル | ||||||
| タイトル | Heavy-Ion Irradiation Disrupts Cancer Stem Cells And Completely Controls Transplantable Human Colon Cancer In Nude Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference output | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sai, Sei
× Sai, Sei× Matsumoto, Yoshitaka× Tsujii, Hirohiko× Okayasu, Ryuichi× 崔 星× 松本 孔貴× 辻井 博彦× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To clarify histopathological changes and molecular mechanisms of high LET heavy-ion radiation in the treatment of transplantable human colon cancer in Balb/c-nu/nu mice. Methods: HCT116 cells were inoculated into the mice and were irradiated with carbon-ion (C290, 50keV/microm, SOBP) or X-ray when the xenograft tumors grew to a certain size. Histopathological analysis and immunohistochemical study were carried out by the hematoxylin and eosin (HE) and avidin-biotin-peroxidase complex (ABC) methods. Results: Both X-rays (30Gy) and carbon-ion radiation (30Gy) effectively suppressed tumor growth. However, the tumors were re-grew in the X-ray irradiated mice after 4 weeks, in contrast, all the tumors were regressed and consequently the tumor size was remarkably decreased or completely disappeared without any relapse or re-growth. Tumor-supplying vessels were also reduced in carbon-ion irradiated mice compared to those of X-ray irradiated mice when examined one month later. Expression of vascular endothelial growth factor (VEGF), beta-catenin and cancer stem cell marker CD133+ was predominantly suppressed by carbon ion irradiation; by contrast, X-rays increased the expression of these proteins. Conclusions: Heavy-ion irradiation can radically control tumor growth compared to X-rays, and the suppression of tumor-induced angiogenesis and inhibition of cancer stem cells are considered as one of the most important molecular mechanisms of heavy ion radiotherapy. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2nd Asian Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2009-05-20 | |||||
| 日付タイプ | Issued | |||||
