{"created":"2023-05-15T14:51:01.591806+00:00","id":69753,"links":{},"metadata":{"_buckets":{"deposit":"f5d147bc-dbc7-4f50-a5fe-b98b990ef320"},"_deposit":{"created_by":1,"id":"69753","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69753"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069753","sets":["10:28"]},"author_link":["684804","684802","684800","684806","684807","684801","684803","684805"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-05-20","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To clarify histopathological changes and molecular mechanisms of high LET heavy-ion radiation in the treatment of transplantable human colon cancer in Balb/c-nu/nu mice.\nMethods: HCT116 cells were inoculated into the mice and were irradiated with carbon-ion (C290, 50keV/microm, SOBP) or X-ray when the xenograft tumors grew to a certain size. Histopathological analysis and immunohistochemical study were carried out by the hematoxylin and eosin (HE) and avidin-biotin-peroxidase complex (ABC) methods.\nResults: Both X-rays (30Gy) and carbon-ion radiation (30Gy) effectively suppressed tumor growth. However, the tumors were re-grew in the X-ray irradiated mice after 4 weeks, in contrast, all the tumors were regressed and consequently the tumor size was remarkably decreased or completely disappeared without any relapse or re-growth. Tumor-supplying vessels were also reduced in carbon-ion irradiated mice compared to those of X-ray irradiated mice when examined one month later. Expression of vascular endothelial growth factor (VEGF), beta-catenin and cancer stem cell marker CD133+ was predominantly suppressed by carbon ion irradiation; by contrast, X-rays increased the expression of these proteins.\nConclusions: Heavy-ion irradiation can radically control tumor growth compared to X-rays, and the suppression of tumor-induced angiogenesis and inhibition of cancer stem cells are considered as one of the most important molecular mechanisms of heavy ion radiotherapy.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"2nd Asian Congress of Radiation Research","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sai, Sei"}],"nameIdentifiers":[{"nameIdentifier":"684800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Yoshitaka"}],"nameIdentifiers":[{"nameIdentifier":"684801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"684802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"684803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔 星","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"684804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 孔貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"684805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"684806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"684807","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Heavy-Ion Irradiation Disrupts Cancer Stem Cells And Completely Controls Transplantable Human Colon Cancer In Nude Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Heavy-Ion Irradiation Disrupts Cancer Stem Cells And Completely Controls Transplantable Human Colon Cancer In Nude Mice"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-05-25"},"publish_date":"2009-05-25","publish_status":"0","recid":"69753","relation_version_is_last":true,"title":["Heavy-Ion Irradiation Disrupts Cancer Stem Cells And Completely Controls Transplantable Human Colon Cancer In Nude Mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:10:49.196221+00:00"}