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ヒト中皮腫細胞におけるマンガン、銅、亜鉛含量とSOD活性の変化
https://repo.qst.go.jp/records/69562
https://repo.qst.go.jp/records/695622f465067-5f04-4b0a-bc75-b082ad96bc39
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-31 | |||||
| タイトル | ||||||
| タイトル | ヒト中皮腫細胞におけるマンガン、銅、亜鉛含量とSOD活性の変化 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
越川, 道子
× 越川, 道子× 長谷川, 純崇× 古川, 高子× 佐賀, 恒夫× 越川 道子× 長谷川 純崇× 古川 高子× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Molecular diagnostics and therapeutics of human mesothelioma using the disease-related markers present major challenges in clinical practice. To identify biochemical alternations that would be the markers in human mesothelioma, we measured the intracellular steady-state level of biologically important trace metals such as manganese (Mn), copper (Cu), zinc (Zn) in a human mesothelial cell line (MeT-5A) and in five human mesothelioma cell lines by inductively coupled plasma-mass spectrometry (ICP-MS). Furthermore, we determined the intracellular levels of manganese-SOD (Mn-SOD) and copper/zinc-SOD (Cu/Zn-SOD) to investigate the relationship between their enzymatic activities and the metal contents. Some mesothelioma cells had significantly higher amounts of Mn or Cu than MeT-5A. Interestingly, all mesothelioma cells highly expressed Mn-SOD compared with MeT-5A. The cells with increased Mn-SOD activity contained higher amounts of Mn, suggesting that intracellular Mn content is positively correlated with Mn-SOD. Therefore, these alterations could be potential disease-related markers of mesothelioma. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第67回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-10-30 | |||||
| 日付タイプ | Issued | |||||
