{"created":"2023-05-15T14:50:53.288157+00:00","id":69562,"links":{},"metadata":{"_buckets":{"deposit":"278e9338-955a-4187-9836-989e0d0bfbda"},"_deposit":{"created_by":1,"id":"69562","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69562"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069562","sets":["10:28"]},"author_link":["682776","682775","682777","682778","682781","682780","682779","682774"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Molecular diagnostics and therapeutics of human mesothelioma using the disease-related markers present major challenges in clinical practice. To identify biochemical alternations that would be the markers in human mesothelioma, we measured the intracellular steady-state level of biologically important trace metals such as manganese (Mn), copper (Cu), zinc (Zn) in a human mesothelial cell line (MeT-5A) and in five human mesothelioma cell lines by inductively coupled plasma-mass spectrometry (ICP-MS). Furthermore, we determined the intracellular levels of manganese-SOD (Mn-SOD) and copper/zinc-SOD (Cu/Zn-SOD) to investigate the relationship between their enzymatic activities and the metal contents. Some mesothelioma cells had significantly higher amounts of Mn or Cu than MeT-5A. Interestingly, all mesothelioma cells highly expressed Mn-SOD compared with MeT-5A. The cells with increased Mn-SOD activity contained higher amounts of Mn, suggesting that intracellular Mn content is positively correlated with Mn-SOD. Therefore, these alterations could be potential disease-related markers of mesothelioma.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第67回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"越川, 道子"}],"nameIdentifiers":[{"nameIdentifier":"682774","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川, 純崇"}],"nameIdentifiers":[{"nameIdentifier":"682775","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 高子"}],"nameIdentifiers":[{"nameIdentifier":"682776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"682777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"越川 道子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682778","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 純崇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682781","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ヒト中皮腫細胞におけるマンガン、銅、亜鉛含量とSOD活性の変化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト中皮腫細胞におけるマンガン、銅、亜鉛含量とSOD活性の変化"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-31"},"publish_date":"2008-10-31","publish_status":"0","recid":"69562","relation_version_is_last":true,"title":["ヒト中皮腫細胞におけるマンガン、銅、亜鉛含量とSOD活性の変化"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:13:03.049353+00:00"}