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中皮腫の増殖に関わる遺伝子の大規模スクリーニング
https://repo.qst.go.jp/records/69561
https://repo.qst.go.jp/records/69561f739cc95-eaff-4e2c-90f9-8b7cfa3bea1f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-31 | |||||
| タイトル | ||||||
| タイトル | 中皮腫の増殖に関わる遺伝子の大規模スクリーニング | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
須藤, 仁美
× 須藤, 仁美× 辻, 厚至× 曽川, 千鶴× 原田, 良信× 樋野, 興夫× 佐賀, 恒夫× 須藤 仁美× 辻 厚至× 曽川 千鶴× 原田 良信× 佐賀 恒夫 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Malignant mesothelioma is a highly aggressive tumor and triggered by past exposure to asbestos dust and fibers. Although this tumor was once rare, the incidence is expected to increase worldwide over the next several decades as a result of high consumption of asbestos. Currently no single widely accepted treatment for mesothelioma results in a cure. To develop effective drug treatment of human cancer requires identification of therapeutic molecular targets. Thus we performed a large-scale functional screening for identification of target genes associated with proliferation in mesothelioma cells using a genome-wide small interfering RNA library. We determined that knockdown of 39 genes apparently suppressed cell proliferation in mesothelioma. According to an apoptosis assay of knockdown cells using microscopic and flow cytometry, at least seven genes of them would be involved in anti-apoptotic function. Functional characterization of these seven genes may help to understand the new molecular mechanisms of apoptosis. These genes might be new molecular targets of therapeutic treatment for malignant mesothelioma. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第67回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-10-30 | |||||
| 日付タイプ | Issued | |||||
