@misc{oai:repo.qst.go.jp:00069561,
 author = {須藤, 仁美 and 辻, 厚至 and 曽川, 千鶴 and 原田, 良信 and 樋野, 興夫 and 佐賀, 恒夫 and 須藤 仁美 and 辻 厚至 and 曽川 千鶴 and 原田 良信 and 佐賀 恒夫},
 month = {Oct},
 note = {Malignant mesothelioma is a highly aggressive tumor and triggered by past exposure to asbestos dust and fibers. Although this tumor was once rare, the incidence is expected to increase worldwide over the next several decades as a result of high consumption of asbestos. Currently no single widely accepted treatment for mesothelioma results in a cure. To develop effective drug treatment of human cancer requires identification of therapeutic molecular targets. Thus we performed a large-scale functional screening for identification of target genes associated with proliferation in mesothelioma cells using a genome-wide small interfering RNA library. We determined that knockdown of 39 genes apparently suppressed cell proliferation in mesothelioma. According to an apoptosis assay of knockdown cells using microscopic and flow cytometry, at least seven genes of them would be involved in anti-apoptotic function. Functional characterization of these seven genes may help to understand the new molecular mechanisms of apoptosis. These genes might be new molecular targets of therapeutic treatment for malignant mesothelioma., 第67回日本癌学会学術総会},
 title = {中皮腫の増殖に関わる遺伝子の大規模スクリーニング},
 year = {2008}
}